Appropriate Development of the Liver Treg Compartment Is Modulated by the Microbiota and Requires TGF-β and MyD88

Figure 3

The increased frequency of FoxP3⁺CD4⁺ cells in postnatal liver reverses in the adult. (a) Liver and spleen FoxP3⁺CD4⁺ frequency data from BALB/c-background mice prior to weaning are displayed. Statistical analysis was by 2-way ANOVA. (b) FoxP3⁺CD4⁺ frequency data from preweaned mice (age 1-2 weeks) and adult mice (age 6 weeks; age 13.5 weeks) are shown. For 1-2 weeks, data for 6- to 8-day-old mice were combined with data from 11- to 12-day-old mice. to 12 mice per time point. Statistical analyses used the nonparametric Mann-Whitney test.

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