Appropriate Development of the Liver Treg Compartment Is Modulated by the Microbiota and Requires TGF-β and MyD88

Figure 4

The increased frequency of FoxP3⁺CD4⁺ cells in postnatal liver depends on TGF-β1. NPC were isolated from thymus, spleen, and liver of BALB/c-background .Tgfb1 ^+/− mice and littermate .Tgfb1 ^−/− mice at the indicated ages. (a) Frequency data for FoxP3⁺CD4⁺ cells are shown. (b) Density data for FoxP3⁺CD4⁺ cells are shown. (c) Data for spleen and liver are shown for Tgfb1 ^+/− mice and Tgfb1 ^−/− mice. to 9 mice per group at each time point. Statistical analyses were by 2-way ANOVA.

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