Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO
Figure 2
Cathepsin B activation in MARCO −/− and WT AM exposed to silica. MARCO−/− AM and WT AM were stimulated with or without LPS (20 ng/mL) and then exposed to silica (100 μg/mL) for 2 hrs prior to cathepsin B activity assay. Mean ± SEM cathepsin B activity where white bar indicates WT AM and grey bar indicates MARCO−/− AM. Hashtag indicates compared to MARCO−/− unstimulated (cells only) group.
