Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO
Figure 9
Cholesterol trafficking modifier U18666A decreases WT AM response to silica (50 μg/mL). (a) Cell viability at 24 hrs after particle exposure by MTS assay. (b) IL-1β release 24 hrs following silica exposure cocultured with LPS (20 ng/mL) to stimulate NF-κB activation. Asterisks indicate statistical significance at compared to corresponding control condition. Hashtags indicate significance at compared to baseline silica-exposed response, .
