Research Article

Fusion-Expressed CTB Improves Both Systemic and Mucosal T-Cell Responses Elicited by an Intranasal DNA Priming/Intramuscular Recombinant Vaccinia Boosting Regimen

Table 1

Mice immunization schedule.

GroupNo. of miceWeek 0 (50  g/mouse)Week 2 (50  g/mouse)Week 4 (50  g/mouse)Week 7 (1E6pfu/mouse)Week 9

A5pSV1.0pSV1.0pSV1.0WT TTVEuthanized
B5pSV-OVApSV-OVApSV-OVArTTV-OVAEuthanized
C5pSV-OVApSV-OVApSV-OVArTTV-OVA-CTBEuthanized
D4pSV-OVA-CTBpSV-OVA-CTBpSV-OVA-CTBrTTV-OVAEuthanized
E5pSV-OVA-CTBpSV-OVA-CTBpSV-OVA-CTBrTTV-OVA-CTBEuthanized