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| Instrument | NOVA View | AKLIDES | EUROPattern | Image Navigator | Helios | ZENIT G Sight |
|
| Manufacturer | INOVA diagnostics | Medipan | Euroimmun | Immunoconcepts | Aesku | Menarini |
|
| LIMS connection (software) | Yes
(QUANTA Link) | Yes (system independent, standard XML interface) | Yes (EUROLabOffice) | Yes (direct)
Optional: lab traffic control | Yes (direct)
Optional: Aesku.Lab middleware | Yes (ZenIT) |
|
| Slide identification via barcode | Yes by handheld scanner | Yes by handheld scanner | Yes by integrated scanner | Yes | Yes by integrated scanner | Yes by integrated scanner |
|
| Loading capacity | 5 slides
(up to 60 wells) | 5 slides
(up to 60 wells) | 50 slides
(up to 500 wells) | 4 slides
(up to 84 wells) | 20 slides
(up to 240 wells) | 5 slides
(up to 70 wells) |
|
| Image acquisition speed | ~45 s/well for 3 images | ~40 s/well | <20 s/well | ~25 s/well for 4 images | 10 s/picture Customizable from 1 to 10 images | >60 s/well
number of pictures: 5 (small scan), 50 (medium scan), or 220 (full scan) |
|
| 100% QC for substrate and process integrity/counterstaining | Yes/DAPI | Yes/DAPI | Yes/Propidium iodide | None/None | None/None | None/None |
|
| Automatic pos./neg. discrimination incl. presorting of images | Yes | Yes | Yes | Yes | Yes | Yes |
|
| Batchwise verification of negative samples | Yes | Yes | Yes | Yes | Yes | Yes |
|
| Automatic pattern recognition | Yes | Yes | Yes | No | No | Yes |
|
| Pattern Analysis method | Pattern recognition by mathematical algorithm | Pattern recognition by mathematical algorithm | Pattern recognition by mathematical algorithm | No pattern matching capabilities | No pattern matching capabilities | Pattern recognition by mathematical algorithm |
|
| Number of recognizable ANA staining pattern list out | 6
Homogeneous
Speckled
Centromere
Nucleolar
Nuclear dot
Cytoplasm
Negative
Positive unrecognized | 10
Homogeneous
Speckled
Centromere
Nucleolar
Nuclear dot
Cytoplasm
Negative
Positive unrecognized
| 8
Homogeneous
Speckled
Centromere
Nucleolar
Nuclear dot
Cytoplasm
Negative
Nuclear rim
Mixed pattern
mitotic | None | None | 5
Homogeneous
Speckled
Centromere
Nucleolar
Cytoplasm
Negative |
|
| Analysis of mixed staining pattern | Limited (homogeneous/
nucleolar) | Yes | Yes | No | No | No |
|
| Merged results per patient (different dilutions) | Yes | Yes | Yes | Yes | Yes | Yes |
|
| Final result validation possible while system processes remaining samples | Yes | No | Yes | Yes | Yes | No |
|
| Instrument calibration to minimize variability | Yes | Yes | Yes | Yes | Yes | No |
|
| Integration with slide processing in 1 instrument | No | No | No | No | Yes | No |
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