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Journal of Immunology Research
Volume 2014, Article ID 361419, 14 pages
http://dx.doi.org/10.1155/2014/361419
Research Article

In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis

1Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
2Unitat de Toxicologia Experimental y Ecotoxicologia (UTOX), Parc Cientific de Barcelona, 08028 Barcelona, Spain
3Immunotoxicology and Allergy Unit, Ageing Research Center, University Foundation, Department of Medicine and Science of Ageing, University “D’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
4Department of Physical and Chemical Sciences, University of L’Aquila, 67100 L’Aquila, Italy

Received 7 May 2014; Accepted 21 May 2014; Published 17 June 2014

Academic Editor: Takemi Otsuki

Copyright © 2014 Anna Poma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. Shah, L. V. Denham, R. E. Jasmine et al., “Drug delivery to the posterior segment of the eye for pharmacologic therapy,” Expert Review of Ophthalmology, vol. 5, no. 1, pp. 75–93, 2010. View at Google Scholar
  2. A. Gutsch, J. Averdung, and H. Muhlenweg, “Von der technischen Entwicklung zum erfolgreichen nanotechnologischen produckt,” Chemie Ingenieur Technik, vol. 77, no. 9, pp. 1377–1392, 2005. View at Google Scholar
  3. M. Fall, M. Guerbet, B. Park, F. Gouriou, F. Dionnet, and J.-P. Morin, “Evaluation of cerium oxide and cerium oxide based fuel additive safety on organotypic cultures of lung slices,” Nanotoxicology, vol. 1, no. 3, pp. 227–234, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Park, P. Martin, C. Harris et al., “Initial in vitro screening approach to investigate the potential health and environmental hazards of Envirox—a nanoparticulate cerium oxide diesel fuel additive,” Particle and Fibre Toxicology, vol. 4, article 12, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. HEI—Health Effects Institute, Evaluation of Human Health Risk from Cerium Added to Diesel Fuel, Flagship Press, North Andover, Mass, USA, 2001.
  6. A. Farfaletti, C. Astorga, G. Martini et al., “Effect of water/fuel emulsions and a cerium-based combustion improver additive on HD and LD diesel exhaust emissions,” Environmental Science and Technology, vol. 39, no. 17, pp. 6792–6799, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Jung, D. B. Kittelson, and M. R. Zachariah, “The influence of a cerium additive on ultrafine diesel particle emissions and kinetics of oxidation,” Combustion and Flame, vol. 142, no. 3, pp. 276–288, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. López-Moreno, G. De La Rosa, J. A. Hernández-Viezcas, J. R. Peralta-Videa, and J. L. Gardea-Torresdey, “X-ray absorption spectroscopy (XAS) corroboration of the uptake and storage of ceo2 nanoparticles and assessment of their differential toxicity in four edible plant species,” Journal of Agricultural and Food Chemistry, vol. 58, no. 6, pp. 3689–3693, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. F. R. Cassee, E. C. Van Balen, C. Singh et al., “Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive,” Critical Reviews in Toxicology, vol. 41, no. 3, pp. 213–229, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. V. R. Velasco, F. D. Sarruf, I. M. N. Salgado-Santos, C. A. Haroutiounian-Filho, T. M. Kaneko, and A. R. Baby, “Broad spectrum bioactive sunscreens,” International Journal of Pharmaceutics, vol. 363, no. 1-2, pp. 50–57, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Bennat and C. C. Müller-Goymann, “Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter,” International Journal of Cosmetic Science, vol. 22, no. 4, pp. 271–283, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Waris and H. Ahsan, “Reactive oxygen species: role in the development of cancer and various chronic conditions,” Journal of Carcinogenesis, vol. 5, article 14, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Izu, W. Shin, I. Matsubara, and N. Murayama, “Development of resistive oxygen sensors based on cerium oxide thick film,” Journal of Electroceramics, vol. 13, no. 1—3, pp. 703–706, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Schubert, R. Dargusch, J. Raitano, and S.-W. Chan, “Cerium and yttrium oxide nanoparticles are neuroprotective,” Biochemical and Biophysical Research Communications, vol. 342, no. 1, pp. 86–91, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. A. L. Chun, “Seeing with ceria,” Nature Nanotechnology, 2006. View at Publisher · View at Google Scholar
  16. J. Niu, A. Azfer, L. M. Rogers, X. Wang, and P. E. Kolattukudy, “Cardioprotective effects of cerium oxide nanoparticles in a transgenic murine model of cardiomyopathy,” Cardiovascular Research, vol. 73, no. 3, pp. 549–559, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Linse, C. Cabaleiro-Lago, W.-F. Xue et al., “Nucleation of protein fibrillation by nanoparticles,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 21, pp. 8691–8696, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Xia, M. Kovochich, M. Liong et al., “Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties,” ACS Nano, vol. 2, no. 10, pp. 2121–2134, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Chen, S. Patil, S. Seal, and J. F. McGinnis, “Nanoceria particles prevent roi-induced blindness,” Advances in Experimental Medicine and Biology, vol. 613, pp. 53–59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. L. De Marzi, A. Monaco, J. De Lapuente et al., “Cytotoxicity and genotoxicity of ceria nanoparticles on different cell lines in vitro,” International Journal of Molecular Sciences, vol. 14, no. 2, pp. 3065–3077, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. D. G. Olmedo, D. R. Tasat, M. B. Guglielmotti, and R. L. Cabrini, “Effect of titanium dioxide on the oxidative metabolism of alveolar macrophages: an experimental study in rats,” Journal of Biomedical Materials Research A, vol. 73, no. 2, pp. 142–149, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. S. K. Nalabotu, M. B. Kolli, W. E. Triest et al., “Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats,” International Journal of Nanomedicine, vol. 6, pp. 2327–2335, 2011. View at Google Scholar · View at Scopus
  23. M. T. Tseng, X. Lu, X. Duan et al., “Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria,” Toxicology and Applied Pharmacology, vol. 260, no. 2, pp. 173–182, 2012. View at Publisher · View at Google Scholar · View at Scopus