Review Article

The Spectrum of Anti-Chromatin/Nucleosome Autoantibodies: Independent and Interdependent Biomarkers of Disease

Table 1

ANuA in SLE compared to controls*.

Authors reference ANuA in SLE cohort
sensitivity/specificity ( )
% anti-dsDNA in SLE cohortANuA clinical and serological associations

Sardeto et al., 2012 [88]62/100 (92)40Disease activity, anti-dsDNA
Suleiman et al., 2009 [89]52/98 (90)37Disease activity, anti-DNA
Kim et al., 2008 [95]98/78 (100)nrLeucopenia, low complement, disease activity, anti-dsDNA
Bossuyt et al., 2008 [103]78/73 (40)65Proteinuria, disease flare, ANuA but not anti-dsDNA found in TNF alpha inhibitor related ANA
Grootscholten et al., 2007 [83] 81/nr (52) (LSLN)96Disease activity but not disease course, LN, anti-histone, anti-C1q
Su et al., 2007 [96]62/98 (233)nrDisease activity, malar rash, arthralgia, anti-dsDNA
Düzgün et al., 2007 [6]55/98 (131)nrDisease activity, LN, anti-dsDNA
Tikly et al., 2007 [97]45/94 (86)nrDisease activity, discoid lupus/malar rash, anti-dsDNA, aCL
Braun et al., 2007 [94]64/99 (78)Disease activity, anti-dsDNA, anti-C1q
Campos et al., 2006 [110]53/98 (74) (JSLE)54Disease activity, malar rash, hemolytic anemia, low complement, anti-dsDNA
Simón et al., 2004 [85]100/97 (73)63LN, malar rash, arthritis, oral ulcers, pleuritis, disease activity, renal damage
Ghirardello et al., 2004 [93]86/95 (101)69Hematological, anti-dsDNA
Cairns et al., 2003 [28]64/99 (95)nrLN, hematological, anti-dsDNA
Cervera et al., 2003 [29]69/92 (100)nrLN, anti-dsDNA
Min et al., 2002 [26]76/98 (129)79Disease activity, low complement, anti-dsDNA
Amoura et al., 2000 [27]72/90 (120)nrDisease activity, LN

aCL: anticardiolipin; CLE: cutaneous lupus erythematosus, ANuA: anti-nucleosome antibodies; dsDNA: double-stranded DNA; JSLE: juvenile systemic lupus erythematosus; LN: lupus nephritis; nr: not reported; NRL: nonrenal lupus; LSLN: longitudinal study of lupus nephritis; nr: not reported.
*Some data adapted from [4, 8].