Research Article
Analytical and Clinical Comparison of Two Fully Automated Immunoassay Systems for the Diagnosis of Celiac Disease
Table 2
Clinical sensitivity and specificity.
| | Assay | Sensitivity % (95% CI) | Specificity % (95% CI) | LR+/LR− |
| | QF h-tTG IgA | 90.5 (81.5–96.1) | 99.3 (96.0–100.0) | 124.95/0.10 | | h-tTG IgA FEIA (equivocal = positive) | 90.5 (81.5–96.1) | 99.3 (96.0–100.0) | 124.95/0.10 | | h-tTG IgA FEIA (equivocal = negative) | 75.7 (64.3–84.9) | 99.3 (96.0–100.0) | 104.43/0.25 | | QF h-tTG IgG | 35.1 (24.4–47.1) | 99.3 (96.0–100.0) | 48.49/0.65 | | h-tTG IgG FEIA (equivocal = positive) | 37.8 (26.8–49.9) | 100.0 (97.4–100.0) | +∞/0.62 | | h-tTG IgG FEIA (equivocal = negative) | 27.0 (17.4–38.6) | 100.0 (97.4–100.0) | +∞/0.73 | | QF DGP IgA | 70.3 (58.5–80.3) | 98.6 (94.9–99.8) | 48.49/0.30 | | DGP IgA FEIA (equivocal = positive) | 62.2 (50.1–73.2) | 97.1 (92.7–99.2) | 21.45/0.39 | | DGP IgA FEIA (equivocal = negative) | 52.7 (40.7–64.4) | 97.1 (92.7–99.2) | 18.18/0.49 | | QF DGP IgG | 75.7 (64.3–84.9) | 96.4 (91.7–98.8) | 20.89/0.25 | | DGP IgG FEIA (equivocal = positive) | 73.0 (61.4–82.6) | 98.6 (94.9–99.8) | 50.35/0.27 | | DGP IgG FEIA (equivocal = negative) | 56.8 (44.7–68.2) | 98.6 (94.9–99.8) | 39.16/0.44 |
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