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Journal of Immunology Research
Volume 2014, Article ID 392170, 10 pages
http://dx.doi.org/10.1155/2014/392170
Research Article

Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate

1Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
2Fleet Bioprocessing Ltd., Pale Lane Farm, Hartley Wintney RG27 8DH, UK
3College of Life and Environmental Sciences, University of Exeter, Exeter EX4 4QD, UK

Received 18 December 2013; Revised 14 March 2014; Accepted 2 April 2014; Published 7 May 2014

Academic Editor: Louise Pitt

Copyright © 2014 Andrew E. Scott et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. J. Currie, “Melioidosis: an important cause of pneumonia in residents of and travellers returned from endemic regions,” European Respiratory Journal, vol. 22, no. 3, pp. 542–550, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. B. J. Currie, D. A. B. Dance, and A. C. Cheng, “The global distribution of Burkholderia pseudomallei and melioidosis: an update,” Transactions of the Royal Society of Tropical Medicine & Hygiene, vol. 102, supplement 1, pp. S1–S4, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. W. J. Wiersinga, T. van der Poll, N. J. White, N. P. Day, and S. J. Peacock, “Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei,” Nature Reviews Microbiology, vol. 4, no. 4, pp. 272–282, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. B. J. Currie, D. A. Fisher, D. M. Howard et al., “Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature,” Clinical Infectious Diseases, vol. 31, no. 4, pp. 981–986, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Limmathurotsakul, S. Wongratanacheewin, N. Teerawattanasook et al., “Increasing incidence of human melioidosis in northeast Thailand,” The American Journal of Tropical Medicine and Hygiene, vol. 82, no. 6, pp. 1113–1117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. B. J. Currie, D. A. Fisher, N. M. Anstey, and S. P. Jacups, “Melioidosis: acute and chronic disease, relapse and re-activation,” Transactions of the Royal Society of Tropical Medicine & Hygiene, vol. 94, no. 3, pp. 301–304, 2000. View at Google Scholar · View at Scopus
  7. R. W. Titball, P. Russell, J. Cuccui et al., “Burkholderia pseudomallei: animal models of infection,” Transactions of the Royal Society of Tropical Medicine & Hygiene, vol. 102, supplement 1, pp. S111–S116, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. L. Yingst, P. Facemire, L. Chuvala, D. Norwood, M. Wolcott, and D. A. Alves, “Pathological findings and diagnostic implications of a rhesus macaque (Macaca mulatta) model of aerosol-exposure melioidosis (Burkholderia pseudomallei),” Journal of Medical Microbiology, vol. 63, no. 1, pp. 118–128, 2014. View at Publisher · View at Google Scholar
  9. M. Nelson, R. E. Dean, F. J. Salguero et al., “Development of an acute model of inhalational melioidosis in the common marmoset (Callithrix jacchus),” International Journal of Experimental Pathology, vol. 92, no. 6, pp. 428–435, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Dance, “Treatment and prophylaxis of melioidosis,” International Journal of Antimicrobial Agents, vol. 43, no. 4, pp. 310–318, 2014. View at Publisher · View at Google Scholar
  11. S. J. Peacock, D. Limmathurotsakul, Y. Lubell et al., “Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes,” PLoS Neglected Tropical Diseases, vol. 6, no. 1, Article ID e1488, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. E. B. Silva and S. W. Dow, “Development of Burkholderia mallei and pseudomallei vaccines,” Frontiers in Cellular and Infection Microbiology, vol. 3, article 10, 2013. View at Publisher · View at Google Scholar
  13. N. Patel, L. Conejero, M. de Reynal, A. Easton, G. J. Bancroft, and R. W. Titball, “Development of vaccines against Burkholderia pseudomallei,” Frontiers in Microbiology, vol. 2, article 198, 2011. View at Publisher · View at Google Scholar
  14. L.-C. Choh, G.-H. Ong, K. M. Vellasamy et al., “Burkholderia vaccines: are we moving forward?” Frontiers in Cellular and Infection Microbiology, vol. 3. article 5, 2013. View at Publisher · View at Google Scholar
  15. M. Nelson, J. L. Prior, M. S. Lever, H. E. Jones, T. P. Atkins, and R. W. Titball, “Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis,” Journal of Medical Microbiology, vol. 53, no. 12, pp. 1177–1182, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Heiss, M. N. Burtnick, R. A. Roberts, I. Black, P. Azadi, and P. J. Brett, “Revised structures for the predominant O-polysaccharides expressed by Burkholderia pseudomallei and Burkholderia mallei,” Carbohydrate Research, vol. 381, pp. 6–11, 2013. View at Publisher · View at Google Scholar
  17. Y. A. Knirel, N. A. Paramonov, A. S. Shashkov et al., “Structure of the polysaccharide chains of Pseudomonas pseudomallei lipopolysaccharides,” Carbohydrate Research, vol. 233, pp. 185–193, 1992. View at Publisher · View at Google Scholar · View at Scopus
  18. M. B. Perry, L. L. MacLean, T. Schollaardt, L. E. Bryan, and M. Ho, “Structural characterization of the lipopolysaccharide O antigens of Burkholderia pseudomallei,” Infection and Immunity, vol. 63, no. 9, pp. 3348–3352, 1995. View at Google Scholar · View at Scopus
  19. D. DeShazer, P. J. Brett, and D. E. Woods, “The type II O-antigenic polysaccharide moiety of Burkholderia pseudomallei lipopolysaccharide is required for serum resistance and virulence,” Molecular Microbiology, vol. 30, no. 5, pp. 1081–1100, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. S. M. Jones, J. F. Ellis, P. Russell, K. F. Griffin, and P. C. F. Oyston, “Passive protection against Burkholderia pseudomallei infection in mice by monoclonal antibodies against capsular polysaccharide, lipopolysaccharide or proteins,” Journal of Medical Microbiology, vol. 51, no. 12, pp. 1055–1062, 2002. View at Google Scholar · View at Scopus
  21. P. J. Brett and D. E. Woods, “Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates,” Infection and Immunity, vol. 64, no. 7, pp. 2824–2828, 1996. View at Google Scholar · View at Scopus
  22. S. Zhang, S.-H. Feng, B. Li et al., “In vitro and in vivo studies of monoclonal antibodies with prominent bactericidal activity against Burkholderia pseudomallei and Burkholderia mallei,” Clinical and Vaccine Immunology, vol. 18, no. 5, pp. 825–834, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. K. E. Stein, “Thymus-independent and thymus-dependent responses to polysaccharide antigens,” The Journal of Infectious Diseases, vol. 165, supplement 1, pp. S49–S52, 1992. View at Google Scholar · View at Scopus
  24. S. Lockhart, “Conjugate vaccines,” Expert Review of Vaccines, vol. 2, no. 5, pp. 633–648, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. A. E. Scott, S. M. Twine, K. M. Fulton et al., “Flagellar glycosylation in Burkholderia pseudomallei and Burkholderia thailandensis,” Journal of Bacteriology, vol. 193, no. 14, pp. 3577–3587, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. S. A. Ngugi, V. V. Ventura, O. Qazi et al., “Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis,” Vaccine, vol. 28, no. 47, pp. 7551–7555, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Chart, “LPS: isolation and characterisation,” in Methods in Practical Laboratory Bacteriology, H. Chart, Ed., pp. 11–20, CRC Press, Boca Raton, Fla, USA, 1994. View at Google Scholar
  28. K. Sinha, M. Box, G. Lalli et al., “Analysis of mutants of tetanus toxin HC fragment: ganglioside binding, cell binding and retrograde axonal transport properties,” Molecular Microbiology, vol. 37, no. 5, pp. 1041–1051, 2000. View at Publisher · View at Google Scholar
  29. T. Masuko, A. Minami, N. Iwasaki, T. Majima, S.-I. Nishimura, and Y. C. Lee, “Carbohydrate analysis by a phenol-sulfuric acid method in microplate format,” Analytical Biochemistry, vol. 339, no. 1, pp. 69–72, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Sarkar-Tyson, S. J. Smither, S. V. Harding, T. P. Atkins, and R. W. Titball, “Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders,” Vaccine, vol. 27, no. 33, pp. 4447–4451, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. C. M. Snapper and W. E. Paul, “Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production,” Science, vol. 236, no. 4804, pp. 944–947, 1987. View at Google Scholar · View at Scopus
  32. M. N. Burtnick, P. J. Brett, and D. E. Woods, “Molecular and physical characterization of Burkholderia mallei O antigens,” Journal of Bacteriology, vol. 184, no. 3, pp. 849–852, 2002. View at Google Scholar · View at Scopus
  33. T. E. West, R. K. Ernst, M. J. Jansson-Hutson, and S. J. Skerrett, “Activation of Toll-like receptors by Burkholderia pseudomallei,” BMC Immunology, vol. 9, article 46, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. I. Bekeredjian-Ding and G. Jego, “Toll-like receptors—sentries in the B-cell response,” Immunology, vol. 128, no. 3, pp. 311–323, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. G. D. Healey, S. J. Elvin, M. Morton, and E. D. Williamson, “Humoral and cell-mediated adaptive immune responses are required for protection against Burkholderia pseudomallei challenge and bacterial clearance postinfection,” Infection and Immunity, vol. 73, no. 9, pp. 5945–5951, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Haque, A. Easton, D. Smith et al., “Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection,” The Journal of Infectious Diseases, vol. 193, no. 3, pp. 370–379, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Santanirand, V. S. Harley, D. A. B. Dance, B. S. Drasar, and G. J. Bancroft, “Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei,” Infection and Immunity, vol. 67, no. 7, pp. 3593–3600, 1999. View at Google Scholar · View at Scopus
  38. G.-Y. G. Tan, Y. Liu, S. P. Sivalingam et al., “Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB/c and C57Bl/6 mice,” Journal of Medical Microbiology, vol. 57, no. 4, pp. 508–515, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. G. C. Ulett, N. Ketheesan, and R. G. Hirst, “Cytokine gene expression in innately susceptible BALB/c mice and relatively resistant C57BL/6 mice during infection with virulent Burkholderia pseudomallei,” Infection and Immunity, vol. 68, no. 4, pp. 2034–2042, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. S. C. Cowley, “Editorial: proinflammatory cytokines in pneumonic tularemia: too much too late?” Journal of Leukocyte Biology, vol. 86, no. 3, pp. 469–470, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. B. J. Currie, S. P. Jacups, A. C. Cheng et al., “Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia,” Tropical Medicine & International Health, vol. 9, no. 11, pp. 1167–1174, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. Suputtamongkol, W. Chaowagul, P. Chetchotisakd et al., “Risk factors for melioidosis and bacteremic melioidosis,” Clinical Infectious Diseases, vol. 29, no. 2, pp. 408–413, 1999. View at Google Scholar · View at Scopus
  43. M. R. A. Hassan, S. P. Pani, N. P. Peng et al., “Incidence, risk factors and clinical epidemiology of melioidosis: a complex socio-ecological emerging infectious disease in the Alor Setar region of Kedah, Malaysia,” BMC Infectious Diseases, vol. 10, article 302, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. W. Chaowagul, Y. Suputtamongkol, D. A. B. Dance, A. Rajchanuvong, J. Pattara-Arechachai, and N. J. White, “Relapse in melioidosis: incidence and risk factors,” The Journal of Infectious Diseases, vol. 168, no. 5, pp. 1181–1185, 1993. View at Google Scholar · View at Scopus