A Mycobacterium bovis BCG-Naked DNA Prime-Boost Vaccination Strategy Induced CD4⁺ and CD8⁺ T-Cell Response against Mycobacterium tuberculosis Immunogens

Figure 1

Analysis of the antibody responses via testing the IgG, IgG1, and IgG2a by ELISA. Animals were immunized and harvested at the indicated time points. The sera were obtained and tested for specific antibody levels. Results are expressed as mean ± standard errors. ^∗𝑃<0.01 versus PBST, BCG-C, BCG-P, BCG-C+pcDNA3.1, or BCG-P+pcDNA3.1 groups. ^#𝑃<0.01 versus BCG-P+3.1-69 or BCG-P+3.1-72 group. ^◊𝑃<0.05 versus BCG-P+3.1-72 group. ^☆𝑃<0.05 versus BCG-P+3.1-69, BCG-C+3.1-72 or BCG-P+3.1-72 group.

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