Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target
Figure 1
Hematoxylin eosin staining for synovial tissue (original magnification ×200). Hematoxylin eosin staining distinguished synovium of RA patients from synovium of controls. Inflammatory cell infiltration, synovial cell proliferation, and pannus formation are visible in synovium of RA patients ((a), (c)). Fewer inflammatory changes are detectable in synovium from knee trauma patients ((b), (d)). Red arrow: synovial cell proliferation. Black arrow: pannus formation.
