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Journal of Immunology Research
Volume 2014 (2014), Article ID 402038, 10 pages
Review Article

Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye?

1Experimental Research, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, 05152 000 São Paulo, SP, Brazil
2Programa de Alergia e Imunopatologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Av. Dr. Arnaldo, 455, 01418 200 São Paulo, SP, Brazil

Received 4 February 2014; Revised 25 March 2014; Accepted 25 March 2014; Published 16 April 2014

Academic Editor: Ethan M. Shevach

Copyright © 2014 H. G. Alvarenga and L. Marti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fibroblastic reticular cells (FRCs) are stromal cells found in secondary lymphoid organ. Despite its structural function in the lymph nodes being well established, recent studies indicate that the FRCs also play a key role in immunological processes, associated with cell transit, immune response, and cells activation quality, and contribute to peripheral tolerance. To this end, we focus this review on lymph nodes FRC characterization and discuss functional aspects such as production of cytokines and chemokines and their involvement in the immune response, seeking to establish whether certain subsets have a more functional specialization.