Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies
Epitope mapping of anti-HMGCR antibodies. DyLight680 showed no background interaction with the secondary antibody (a); incubation with anti-HMGCR positive serum revealed a number of reactive peptides (b). Epitopes identified using solid phase array are shown in (c). Sequences in yellow were selected for soluble peptide synthesis based on reactivity and surface exposure.