Journal of Immunology Research / 2014 / Article / Fig 5

Research Article

Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies

Figure 5

Epitope mapping of anti-HMGCR antibodies. DyLight680 showed no background interaction with the secondary antibody (a); incubation with anti-HMGCR positive serum revealed a number of reactive peptides (b). Epitopes identified using solid phase array are shown in (c). Sequences in yellow were selected for soluble peptide synthesis based on reactivity and surface exposure.
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(a)
405956.fig.005b
(b)
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(c)