Journal of Immunology Research / 2014 / Article / Tab 1

Research Article

Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies

Table 1

Clinical and serological data of anti-HMGCR positive sera.

ID ALBIA (>20) CIA (>10,000) ELISA (>20) Gender Age Statin ADO (ys) CK* (25–160 U/L) Necrosis

3 928 201891 149.2 F62 + 59 1000 +
5 496 213681 113.5 F53 52 13777 +
6 960 259814 193.1 M59 47 8500 +
9 1008 291111 184.9 F22 18 ND +
10 784 138696 284.3 F16 13 1500 +
11 512 244281 381.8 F 66 + 60 6500 +
13 768 179810 153.5 F 69 + 63 492 Very few fiber
15 320 184190 174.7 F 44 21 ND +
17 800 254442 139.4 F 60 54 6000 +
18 1136 218777 126.3 F 53 + 48 4106 +
26 280 119734 57.9 M 67 + 66 5700 +
27 576 180528 88.9 F 17 12 17000 +
28 528 288198 93.8 M 65 52 500 +
29 84 79904 29.8 F 75 + 73 7429 No biopsy
30 196 135149 49.7 F 72 + 68 3700 +
31 608 250484 324.1 F 35 26 5700 +
32 424 141861 932.1 M 81 82 ND +
34 400 208075 118.5 F 84 + 83 4119 ND
37 212 160034 83.3 F 20 15 612 +
39 142 115671 56.6 F 67 + 58 2000

CK: creatinine kinase; CIA: chemiluminescence immunoassay; ALBIA: addressable laser bead assay; ADO: age at disease onset; ND: not determined.
*Not all CK values are derived from the time point when serum was obtained for anti-HMGCR testing.