Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies

Table 1

Clinical and serological data of anti-HMGCR positive sera.

ID	ALBIA (>20)	CIA (>10,000)	ELISA (>20)	Gender	Age	Statin	ADO (ys)	CK* (25–160 U/L)	Necrosis
3	928	201891	149.2	F	62	+	59	1000	+
5	496	213681	113.5	F	53	−	52	13777	+
6	960	259814	193.1	M	59	−	47	8500	+
9	1008	291111	184.9	F	22	−	18	ND	+
10	784	138696	284.3	F	16	−	13	1500	+
11	512	244281	381.8	F	66	+	60	6500	+
13	768	179810	153.5	F	69	+	63	492	Very few fiber
15	320	184190	174.7	F	44	−	21	ND	+
17	800	254442	139.4	F	60	−	54	6000	+
18	1136	218777	126.3	F	53	+	48	4106	+
26	280	119734	57.9	M	67	+	66	5700	+
27	576	180528	88.9	F	17	−	12	17000	+
28	528	288198	93.8	M	65	−	52	500	+
29	84	79904	29.8	F	75	+	73	7429	No biopsy
30	196	135149	49.7	F	72	+	68	3700	+
31	608	250484	324.1	F	35	−	26	5700	+
32	424	141861	932.1	M	81	−	82	ND	+
34	400	208075	118.5	F	84	+	83	4119	ND
37	212	160034	83.3	F	20	−	15	612	+
39	142	115671	56.6	F	67	+	58	2000	−

CK: creatinine kinase; CIA: chemiluminescence immunoassay; ALBIA: addressable laser bead assay; ADO: age at disease onset; ND: not determined.
*Not all CK values are derived from the time point when serum was obtained for anti-HMGCR testing.