Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice
Figure 1
Histological and general locomotor analysis after induction of the bilateral electrolytic lesions of the SCN in mice. (a) The SCN of the mice was destroyed by bilateral electrolytic lesions and complete SCN destruction was ascertained by a postmortem histological analysis. Representative pictures of the staining in sham-operated mice (Sham) and mice with disrupted SCN (SCND) are shown. The arrow indicates the SCN area. (b) General locomotor activity of mice housed under LD 12 : 12 conditions was recorded and representative double-blot actograms of the drinking behavior of the mice during 30 days are shown. The black dots indicate the mouse locomotor activity. Horizontal open and solid bars indicate day and night, respectively. Please note that the drinking behavior (usually accompanied by food intake) became arrhythmic in mice with disrupted SCN (SCND).
