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Journal of Immunology Research
Volume 2014, Article ID 530501, 13 pages
http://dx.doi.org/10.1155/2014/530501
Research Article

Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice

1Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China
2Kunming Biological Diversity Regional Center of Large Apparatus and Equipment, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

Received 24 June 2014; Revised 21 November 2014; Accepted 8 December 2014; Published 30 December 2014

Academic Editor: Ghislain Opdenakker

Copyright © 2014 Guang-ping Ruan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Rahman and D. A. Isenberg, “Systemic lupus erythematosus,” The New England Journal of Medicine, vol. 358, no. 9, pp. 929–939, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. J. C. Crispín and G. C. Tsokos, “Novel molecular targets in the treatment of systemic lupus erythematosus,” Autoimmunity Reviews, vol. 7, no. 3, pp. 256–261, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. V. C. Kyttaris, Y.-T. Juang, and G. C. Tsokos, “Immune cells and cytokines in systemic lupus erythematosus: an update,” Current Opinion in Rheumatology, vol. 17, no. 5, pp. 518–522, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Ramanujam and A. Davidson, “Targeting of the immune system in systemic lupus erythematosus,” Expert Reviews in Molecular Medicine, vol. 10, p. e2, 2008. View at Publisher · View at Google Scholar
  5. J. M. Pego-Reigosa and D. A. Isenberg, “Systemic lupus erythematosus: pharmacological developments and recommendations for a therapeutic strategy,” Expert Opinion on Investigational Drugs, vol. 17, no. 1, pp. 31–41, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. A. T. Tieng and E. Peeva, “B-cell-directed therapies in systemic lupus erythematosus,” Seminars in Arthritis and Rheumatism, vol. 38, no. 3, pp. 218–227, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. K. Burt, A. Traynor, L. Statkute et al., “Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus,” Journal of the American Medical Association, vol. 295, no. 5, pp. 527–535, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Smith-Berdan, D. Gille, I. L. Weissman, and J. L. Christensen, “Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells,” Blood, vol. 110, no. 4, pp. 1370–1378, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. L. D. Heinlen, M. T. McClain, J. Merrill et al., “Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms,” Arthritis and Rheumatism, vol. 56, no. 7, pp. 2344–2351, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. H.-J. Lee, J.-H. Choi, J. Jung, J. K. Kim, S. S. Lee, and G. J. Kim, “Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placenta-derived mesenchymal stem cells,” Cell and Tissue Research, vol. 357, no. 1, pp. 145–157, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Erices, P. Conget, and J. J. Minguell, “Mesenchymal progenitor cells in human umbilical cord blood,” British Journal of Haematology, vol. 109, no. 1, pp. 235–242, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. A. Romanov, V. A. Svintsitskaya, and V. N. Smirnov, “Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord,” Stem Cells, vol. 21, no. 1, pp. 105–110, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Fazzi, S. Pacini, V. Carnicelli et al., “Mesodermal progenitor cells (MPCs) differentiate into mesenchymal stromal cells (MSCs) by activation of Wnt5/calmodulin signalling pathway,” PLoS ONE, vol. 6, no. 9, Article ID e25600, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. W.-L. Fu, C.-Y. Zhou, and J.-K. Yu, “A new source of mesenchymal stem cells for articular cartilage repair: MSCs derived from mobilized peripheral blood share similar biological characteristics in vitro and chondrogenesis in vivo as MSCs from bone marrow in a rabbit model,” The American Journal of Sports Medicine, vol. 42, no. 3, pp. 592–601, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Qiao, W. Xu, W. Zhu et al., “Human mesenchymal stem cells isolated from the umbilical cord,” Cell Biology International, vol. 32, no. 1, pp. 8–15, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. D. J. Prockop, “Marrow stromal cells as stem cells for nonhematopoietic tissues,” Science, vol. 276, no. 5309, pp. 71–74, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. A. J. Friedenstein, R. K. Chailakhyan, N. V. Latsinik, A. F. Panasyuk, and I. V. Keiliss-Borok, “Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo,” Transplantation, vol. 17, no. 4, pp. 331–340, 1974. View at Publisher · View at Google Scholar · View at Scopus
  18. X. Chen, M. A. Armstrong, and G. Li, “Mesenchymal stem cells in immunoregulation,” Immunology and Cell Biology, vol. 84, no. 5, pp. 413–421, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. N. S. El-Badri, A. Hakki, A. Ferrari, R. Shamekh, and R. A. Good, “Autoimmune disease: is it a disorder of the microenvironment?” Immunologic Research, vol. 41, no. 1, pp. 79–86, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. A. C. Cordeiro and D. A. Isenberg, “Novel therapies in lupus—focus on nephritis,” Acta Reumatologica Portuguesa, vol. 33, no. 2, pp. 157–169, 2008. View at Google Scholar · View at Scopus
  21. K. Le Blanc, I. Rasmusson, B. Sundberg et al., “Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells,” The Lancet, vol. 363, no. 9419, pp. 1439–1441, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Xu, B. P. Croker, and L. Morel, “The combination of two Sle2 lupus-susceptibility loci and Cdkn2c deficiency leads to T-cell-mediated pathology in B6.Faslpr mice,” Genes and Immunity, vol. 14, no. 6, pp. 373–379, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Sun, K. Akiyama, H. Zhang et al., “Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans,” Stem Cells, vol. 27, no. 6, pp. 1421–1432, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Bonelli, K. Von Dalwigk, A. Savitskaya, J. S. Smolen, and C. Scheinecker, “Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis,” Annals of the Rheumatic Diseases, vol. 67, no. 5, pp. 664–671, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. S.-C. Lin, K.-H. Chen, C.-H. Lin, C.-C. Kuo, Q.-D. Ling, and C.-H. Chan, “The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients,” European Journal of Clinical Investigation, vol. 37, no. 12, pp. 987–996, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. J.-L. Suen and B.-L. Chiang, “CD4+FoxP3+ regulatory T-cells in human systemic lupus erythematosus,” Journal of the Formosan Medical Association, vol. 111, no. 9, pp. 465–470, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Wang, H. Zhang, J. Liang et al., “Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience,” Cell Transplantation, vol. 22, no. 12, pp. 2267–2277, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Sun, D. Wang, J. Liang et al., “Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 62, no. 8, pp. 2467–2475, 2010. View at Publisher · View at Google Scholar · View at Scopus