Comparisons of CVID and IgGSD: Referring Physicians, Autoimmune Conditions, Pneumovax Reactivity, Immunoglobulin Levels, Blood Lymphocyte Subsets, and HLA-A and -B Typing in 432 Adult Index Patients

Table 2

Autoimmune conditions in 432 adult CVID/IgGSD index patients¹.

Condition(s)	CVID ()	IgGSD ()	Value of
Sjögren’s syndrome, % ()	20.6 (7)	6.5 (26)	0.0031
Hashimoto’s thyroiditis, % ()^2	11.8 (4)	2.8 (11)	0.0059
Rheumatoid arthritis, % ()	11.8 (4)	5.3 (21)	0.1199
Gastrointestinal tract, % ()^3	2.9 (1)	2.3 (9)	0.5634
Multiple sclerosis, % ()	2.9 (1)	0.3 (1)	0.1514
Positive ANA, % ()^4	2.9 (1)	3.5 (14)	0.6664
Psoriatic arthritis, % ()	2.9 (1)	1.3 (5)	0.3903
Autoimmune hearing loss, % ()	0	0.3 (1)	0.9213
Autoimmune hemolytic anemia, % ()^5	0	1.0 (4)	0.7196
Diabetes mellitus, type 1, % ()	0	1.3 (5)	0.6624
Graves’ disease, % ()	0	0.5 (2)	0.7820
Inflammatory arthritis, % ()^6	0	0.8 (3)	0.7815
Interstitial cystitis, % ()	0	3.0 (12)	0.3690
Mixed connective tissue disorder, % ()	0	1.3 (5)	0.6624
Myasthenia gravis, % ()	0	1.0 (4)	0.7196
Polymyalgia rheumatica, % ()	0	0.3 (1)	0.9213
Raynaud’s phenomenon, % ()	0	1.8 (7)	0.5610
Reiter’s uveitis, % ()	0	0.3 (1)	0.9213
Sarcoidosis, % ()	0	0.3 (1)	0.9213
Skin and mucous membranes, % ()^7	0	2.3 (9)	0.4747
Systemic lupus erythematosus, % ()	0	3.8 (15)	0.2863
Temporal arteritis, % ()	0	0.5 (2)	0.7820
Thrombotic disorders, % ()^8	0	1.3 (5)	0.6624

CVID, common variable immunodeficiency; IgGSD, IgG subclass deficiency. These autoimmune conditions were diagnosed before referral for CVID/IgGSD evaluation. Comparisons were made with Pearson’s test or Fischer’s exact test, as appropriate. Some patients had two or more autoimmune conditions.
²Hypothyroidism of unreported cause was reported in 11 CVID patients (32.4%) and 52 IgGSD patients (13.1%) ().
³Crohn’s disease (3), ulcerative colitis (3), and pernicious anemia (3).
⁴ANA, antinuclear antibody. Titers of 1 : 80 or greater unexplained by other conditions were defined as positive.
⁵Warm-reacting IgG autoantibody.
⁶Arthritis interpreted as autoimmune but not otherwise specified.
⁷Cutaneous psoriasis (3), erythema nodosum (2), vitiligo (2), alopecia areata (1), and Behcet’s syndrome (1).
⁸Antiphospholipid syndrome (2), anticardiolipin antibody (1), and lupus anticoagulant (2).