Comparisons of CVID and IgGSD: Referring Physicians, Autoimmune Conditions, Pneumovax Reactivity, Immunoglobulin Levels, Blood Lymphocyte Subsets, and HLA-A and -B Typing in 432 Adult Index Patients

Table 4

Blood lymphocytes in 432 adult CVID/IgGSD index patients¹.

Lymphocyte subset	CVID ()	IgGSD ()	Value of
Median CD19+ cells/L	172 (0, 631)	228 (5, 2340)	0.0051
Subnormal CD19+ cells, % ()	5.9 (2)	0.5 (2)	0.0337
Elevated CD19+ cells, % ()	0	2.8 (11)	0.4014
Median CD3+/CD4+ cells/L	783 (57, 1987)	937 (108, 2984)	0.0335
Subnormal CD3+/CD4+ cells, % ()	14.7 (5)	3.8 (15)	0.0147
Elevated CD3+/CD4+ cells, % ()	8.8 (3)	10.8 (43)	0.4988
Median CD3+/CD8+ cells/L	322 (110, 1304)	431 (48, 2106)	0.0453
Subnormal CD3+/CD8+ cells, % ()	0	2.0 (8)	0.5170
Elevated CD3+/CD8+ cells, % ()	0	7.8 (31)	0.0715
CD56+/CD16+ cells/L	118 (39, 295)	146 (4, 626)	0.1988
Subnormal CD56+/CD16+ cells, % ()	0	3.5 (14)	0.3116
Elevated CD56+/CD16+ cells, % ()	0	1.8 (7)	0.5618

CVID, common variable immunodeficiency; IgGSD, IgG subclass deficiency; SD, standard deviation. Blood levels of lymphocyte subsets were measured using flow cytometry. Reference ranges (mean ± 2 SD) are CD19+ 12–645 cells/L; CD3+/CD4+ 359–1,519 cells/µL; CD3+/CD8+ 109–897 cells/L; and CD56+/CD16+ 24–406 cells/L. Subnormal levels were defined as those below the corresponding lower reference limit. Elevated subset levels were defined as those greater than the upper reference limit. Blood lymphocyte levels are expressed as median (range). Comparisons were made with Mann-Whitney test, Pearson’s test, or Fisher’s exact test, as appropriate.