Comparisons of CVID and IgGSD: Referring Physicians, Autoimmune Conditions, Pneumovax Reactivity, Immunoglobulin Levels, Blood Lymphocyte Subsets, and HLA-A and -B Typing in 432 Adult Index Patients

Table 7

Frequencies of HLA-A, -B haplotypes in 432 adult CVID/IgGSD index patients.

Haplotypes	CVID ( chromosomes)	IgGSD ( chromosomes)	Value of
A*01, B*08	13.2 (9)	11.7 (93)	0.7034
A*02, B*44	16.2 (11)	9.9 (79)	0.1053
A*02, B*62	1.5 (1)	0.3 (2)	0.2182
A*02, B*60	0.0 (0)	0.1 (1)	0.9213
A*03, B*07	7.4 (5)	5.7 (45)	0.3569
A*03, B*14	0.0 (0)	1.6 (13)	0.3418
A*03, B*44	2.9 (2)	3.8 (30)	0.5314
A*29, B*44	1.5 (1)	3.4 (27)	0.3370
A*31, B*40	2.9 (2)	0.5 (4)	0.0745
A*32, B*14	1.5 (1)	0.6 (5)	0.3894

HLA, human leukocyte antigen; CVID, common variable immunodeficiency; IgGSD, IgG subclass deficiency. These haplotypes were selected for study because their respective frequencies were significantly greater in Alabama CVID/IgGSD index patients than in population control subjects [10]. Results are displayed as % (). Comparisons were made with Pearson’s test or Fischer’s exact test, as appropriate. These haplotypes accounted for 47.1% of 68 chromosomes 6p in CVID patients and 37.6% of 796 chromosomes 6p in IgGSD patients ().