The Many Faces of Human Leukocyte Antigen-G: Relevance to the Fate of Pregnancy

Figure 2

A simplified illustration of current status regarding the dynamic differences in transcription, mRNA stability, and translation in (extravillous) trophoblast cells between the 14 bp del and 14 bp ins HLA-G alleles. Only the full-length mRNA isoforms are shown for clarity. The relative thicknesses of the specific arrows are putative and should be interpreted with caution. The effect of the HLA-G 14 bp ins/del polymorphism in the 3′-untranslated region (3′UTR) on HLA-G expression may be influenced by linkage disequilibrium with single nucleotide polymorphisms (SNPs) in the 3′UTR, especially the +3142 and +3187 SNPs according to one study [29], and in the 5′-upstream regulatory region. (Based primarily on [1, 30–32]).