Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

Table 1

Proinflammatory interactions of cysteinyl leukotrienes with cells of the innate immune system.

Cell type	Proinflammatory activities triggered by cysLTs
Mast cells [6–8]*	↑ Ca^2+ influx; ↑ Proliferation; ↑ Production of MIP-1β/CCL4
Monocytes/macrophages [9–16]	↑ Migration; ↑ Production of ROS; ↑ Release of MMP-9; ↑ Production of MCP-1 and IL-8; ↑ Production of VEGF
Eosinophils [17–20]	↑ Migration; ↑ Adhesion to vascular endothelium and airway epithelium; ↑ Release of eosinophil-derived neurotoxin and cationic protein
Dendritic cells [14, 21, 22]	↑ Ca^2+ influx; ↑ Production of IL-10; ↑ Production of IL-8
Neutrophils [23–25]	↑ Ca^2+ influx; ↑ Production of nitric oxide and ROS (modest effect); ↑ Sensitization for increased production of ROS and release of MMP-8 following exposure to a second stimulus

∗denotes references cited in the text.