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Journal of Immunology Research
Volume 2014 (2014), Article ID 671050, 8 pages
http://dx.doi.org/10.1155/2014/671050
Research Article

Genetic Diversity of MSP1 Block 2 of Plasmodium vivax Isolates from Manaus (Central Brazilian Amazon)

1Instituto Leonidas e Maria Deane, Fundação Oswaldo Cruz, Rua Teresina 476 Adrianópolis, 69057-070 Manaus, AM, Brazil
2Universidade Federal do Amazonas, Programa Multi-Institucional de Pós-Graduação em Biotecnologia (PPGBIOTEC) Avenida Rodrigo Otávio Jordão Ramos 3000, Coroado, Manaus, AM, Brazil
3Hospital Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Avenida Pedro Teixeira 25, Dom Pedro, 69.040-000 Manaus, AM, Brazil

Received 5 December 2013; Accepted 9 January 2014; Published 27 February 2014

Academic Editor: Wuelton Marcelo Monteiro

Copyright © 2014 Leidiane Amorim Soares et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. A. Guerra, R. E. Howes, A. P. Patil et al., “The international limits and population at risk of Plasmodium vivax transmission in 2009,” PLoS Neglected Tropical Diseases, vol. 4, no. 8, article e774, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. WHO, World Health Organization, World Malaria Report, 2011, http://www.who.int/malaria/publications/atoz/9789241564403/en/index.html.
  3. Sivep-Malaria, “Data of malaria cases in 2012 obtained by epidemiological information system (Sivep-Malaria) from the Ministry of Health in Brazil,” http://portalweb04.saude.gov.br/sivep_malaria/default.asp.
  4. J.-M. Kang, S.-U. Moon, J.-Y. Kim et al., “Genetic polymorphism of merozoite surface protein-1 and merozoite surface protein-2 in Plasmodium falciparum field isolates from Myanmar,” Malaria Journal, vol. 9, no. 1, article 131, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. E. S. Bergmann-Leitner, E. H. Duncan, R. M. Mease et al., “Impact of pre-existing MSP142-allele specific immunity on potency of an erythrocytic Plasmodium falciparum vaccine,” Malaria Journal, vol. 11, no. 315, 2012. View at Publisher · View at Google Scholar
  6. G. J. M. Cowan, A. M. Creasey, K. Dhansarnsombut, A. W. Thomas, E. J. Remarque, and D. R. Cavanagh, “A malaria vaccine based on the polymorphic block 2 region of MSP-1 that elicits a broad serotype-spanning immune response,” PLoS ONE, vol. 6, no. 10, Article ID e26616, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. R. D. Ellis, Y. Wu, L. B. Martin et al., “Phase 1 study in malaria naive adults of BSAM2/Alhydrogel R+CPG, 7909, a blood stage vaccine against P. falciparum malaria,” PLoS ONE, vol. 7, no. 10, Article ID e46094, 2012. View at Publisher · View at Google Scholar
  8. P. A. Nogueira, F. P. Alves, C. Fernandez-Becerra et al., “A reduced risk of infection with Plasmodium vivax and clinical protection against malaria are associated with antibodies against the N terminus but not the C terminus of merozoite surface protein 1,” Infection and Immunity, vol. 74, no. 5, pp. 2726–2733, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. S. H. Sheehy, C. J. A. Duncan, S. C. Elias et al., “Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors,” Molecular Therapy, vol. 19, no. 12, pp. 2269–2276, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. I. S. Soares, M. G. Da Cunha, M. N. Silva, J. M. Souza, H. A. Del Portillo, and M. M. Rodrigues, “Longevity of naturally acquired antibody responses to the N- and C- terminal regions of Plasmodium vivax merozoite surface protein 1,” American Journal of Tropical Medicine and Hygiene, vol. 60, no. 3, pp. 357–363, 1999. View at Google Scholar · View at Scopus
  11. I. S. Soares, G. Levitus, J. M. Souza, H. A. Del Portillo, and M. M. Rodrigues, “Acquired immune responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1 in individuals exposed to malaria,” Infection and Immunity, vol. 65, no. 5, pp. 1606–1614, 1997. View at Google Scholar · View at Scopus
  12. L. M. Storti-Melo, W. C. Souza-Neiras, G. C. Cassiano et al., “Evaluation of the naturally acquired antibody immune response to the Pv 200L N-terminal fragment of Plasmodium vivax merozoite surface protein-1 in four areas of the Amazon Region of Brazil,” American Journal of Tropical Medicine and Hygiene, vol. 84, no. 2 S, pp. 58–63, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. K. K. A. Tetteh and D. J. Conway, “A polyvalent hybrid protein elicits antibodies against the diverse allelic types of block 2 in Plasmodium falciparum merozoite surface protein 1,” Vaccine, vol. 29, no. 44, pp. 7811–7817, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. F. G. Versiani, M. E. Almeida, G. C. Melo et al., “High levels of IgG3 anti ICB2-5 in Plasmodium vivax individuals who did not develop symptoms,” Malaria Journal, vol. 12, no. 294, 2013. View at Publisher · View at Google Scholar
  15. F. G. Versiani, M. E. Almeida, L. A. Mariuba et al., “N-terminal Plasmodium vivax merozoite surface protein-1, a potential subunit for malaria vivax vaccine,” Clinical and Developmental Immunology, vol. 2013, Article ID 965841, 2013. View at Publisher · View at Google Scholar
  16. M. S. Bastos, M. Da Silva-Nunes, R. S. Malafronte et al., “Antigenic polymorphism and naturally acquired antibodies to Plasmodium vivax merozoite surface protein 1 in rural Amazonians,” Clinical and Vaccine Immunology, vol. 14, no. 10, pp. 1249–1259, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Putaporntip, S. Jongwutiwes, N. Sakihama et al., “Mosaic organization and heterogeneity in frequency of allelic recombination of the Plasmodium vivax merozoite surface protein-1 locus,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 25, pp. 16348–16353, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. P. K. Bharti, M. M. Shukla, Y. D. Sharma, and N. Singh, “Genetic diversity in the block 2 region of the merozoite surface protein-1 of Plasmodium falciparum in central India,” Malaria Journal, vol. 11, article 78, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. M. U. Ferreira, Q. Liu, O. Kaneko et al., “Allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from the southwestern Brazilian Amazon,” American Journal of Tropical Medicine and Hygiene, vol. 59, no. 3, pp. 474–480, 1998. View at Google Scholar
  20. N. Khaminsou, O. Kritpetcharat, J. Daduang, L. Charerntanyarak, and P. Kritpetcharat, “Genetic analysis of the merozoite surface protein-1 block 2 allelic types in Plasmodium falciparum clinical isolates from Lao PDR,” Malaria Journal, vol. 10, article 371, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Sakihama, T. Matsuo, T. Mitamura et al., “Relative frequencies of polymorphisms of variation in Block 2 repeats and 5′ recombinant types of Plasmodium falciparum msp1 alleles,” Parasitology International, vol. 53, no. 1, pp. 59–67, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. S. L. Takala, A. A. Escalante, O. H. Branch et al., “Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism,” Infection, Genetics and Evolution, vol. 6, no. 5, pp. 417–424, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Wanji, A. J. Kengne-Ouafo, E. E. Eyong et al., “Genetic diversity of Plasmodium falciparum merozoite surface protein-1 Block 2 in sites of contrasting altitudes and malaria endemicities in the Mount Cameroon region,” American Journal of Tropical Medicine and Hygiene, vol. 86, no. 5, pp. 764–774, 2012. View at Publisher · View at Google Scholar
  24. D. R. Cavanagh, D. Dodoo, L. Hviid et al., “Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria,” Infection and Immunity, vol. 72, no. 11, pp. 6492–6502, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. J. E. Larsen, O. Lund, and M. Nielsen, “Improved method for predicing linear B-cell epitopes,” Immunome Research, vol. 2, no. 2, 2006. View at Google Scholar
  26. H. Singh and G. P. S. Raghava, “ProPred: prediction of HLA-DR binding sites,” Bioinformatics, vol. 17, no. 12, pp. 1236–1237, 2002. View at Google Scholar · View at Scopus
  27. H. A. Del Portillo, S. Longacre, E. Khouri, and P. H. David, “Primary structure of the merozoite surface antigen 1 of Plasmodium vivax reveals sequences conserved between different Plasmodium species,” Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 9, pp. 4030–4034, 1991. View at Google Scholar · View at Scopus
  28. S. Jongwutiwes, C. Putaporntip, and A. L. Hughes, “Bottleneck effects on vaccine-candidate antigen diversity of malaria parasites in Thailand,” Vaccine, vol. 28, no. 18, pp. 3112–3117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. A. A. Escalante, H. M. Grebert, S. C. Chaiyaroj et al., “Polymorphism in the gene encoding the apical membrane antigen-1 (AMA-1) of Plasmodium falciparum X. Asembo Bay Cohort Project,” Molecular and Biochemical Parasitology, vol. 113, no. 2, pp. 279–287, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. D. J. Conway, D. R. Cavanagh, K. Tanabe et al., “A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses,” Nature Medicine, vol. 6, no. 6, pp. 689–692, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Putaporntip, S. Jongwutiwes, T. Iwasaki, H. Kanbara, and A. L. Hughes, “Ancient common ancestry of the merozoite surface protein 1 of Plasmodium vivax as inferred from its homologue in Plasmodium knowlesi,” Molecular and Biochemical Parasitology, vol. 146, no. 1, pp. 105–108, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Takala, O. Branch, A. A. Escalante, S. Kariuki, J. Wootton, and A. A. Lal, “Evidence for intragenic recombination in Plasmodium falciparum: identification of a novel allele family in block 2 of merozoite surface protein-1: asembo Bay Area Cohort Project XIV,” Molecular and Biochemical Parasitology, vol. 125, no. 1-2, pp. 163–171, 2002. View at Google Scholar · View at Scopus
  33. A. A. Escalante, A. A. Lal, and F. J. Ayala, “Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum,” Genetics, vol. 149, no. 1, pp. 189–202, 1998. View at Google Scholar · View at Scopus
  34. G. N. Kiwanuka, “Genetic diversity in Plasmodium falciparum merozoite surface protein 1 and 2 coding genes and its implications in malaria epidemiology: a review of published studies from 1997–2007,” Journal of Vector Borne Diseases, vol. 46, no. 1, pp. 1–12, 2009. View at Google Scholar · View at Scopus
  35. C. Koepfli, A. Ross, B. Kiniboro et al., “Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in papua New Guinea,” PLoS Neglected Tropical Diseases, vol. 5, no. 12, Article ID e1424, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. R. E. Phillips, S. Rowland-Jones, D. F. Nixon et al., “Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition,” Nature, vol. 354, no. 6353, pp. 453–459, 1991. View at Publisher · View at Google Scholar · View at Scopus