Idiopathic Non Cirrhotic Portal Hypertension and Spleno-Portal Axis Abnormalities in Patients with Severe Primary Antibody Deficiencies
Figure 3
Liver biopsy from patient 2 showing features of nodular regenerative hyperplasia. (a-b) Liver parenchyma shows nodules with expanded liver plates surrounded by a rim of atrophic hepatocytes (arrows), in absence of fibrous septa. Portal lymphohistiocytic inflammatory infiltrate with interface activity (white asterisk) is also present ((a) hematoxylin and eosin stain, original magnification 10x; (b) Sirius Red stain, 10x). Congested and dilated sinusoids (megasinusoids) are shown in (c) and (d) ((c) hematoxylin and eosin stain, original magnification 20x; (d) CD34 immunostaining, original magnification 20x); (e) aberrant vascular structures within the portal tract (hematoxylin and eosin, original magnification 20x); (f) fibrotic portal tracts (Sirius Red stain, original magnification 40x).
