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Journal of Immunology Research
Volume 2014, Article ID 672458, 8 pages
Research Article

Idiopathic Non Cirrhotic Portal Hypertension and Spleno-Portal Axis Abnormalities in Patients with Severe Primary Antibody Deficiencies

1Department of Molecular Medicine, Sapienza University of Rome, Viale dell’Università 37, 00186 Rome, Italy
2Gastroenterology, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy
3Department of Experimental Medicine and Pathology, Sapienza University of Rome, Rome, Italy

Received 7 January 2014; Accepted 11 February 2014; Published 31 March 2014

Academic Editor: Roshini Sarah Abraham

Copyright © 2014 Federica Pulvirenti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary table 1: no need of description. the title (Detailed description of characteristics of 112 CVID and 5 XLA patients.) is autoesplicative.

Supplementary Table 2: “The analysis of immunological abnormalities in PAD patients with isolated splenomegaly and in patients with INCPH and/or portal vein enlargemen showed that in comparison to PAD patients without splenomegaly, PAD patients with splenomegaly have a decrease in the frequency of switched memory B cells and an increased frequency of CD21 low B cells. Abnormalities of T cell subsets frequencies were also observed in CD3+CD4+ cells, in naïve CD4+ cells and in CD4+ memory T cells. More profound defects in B and T cell subsets were observed in patients with INCPH and/or portal vein enlargement.”

Supplementary Figure 1: Longitudinal assessment of portal vein (A) and spleen diameter (B) by abdominal ultrasounds in 30 patients (x- axis) with spleno-axis abnormalities.

Portal and spleen diameter were measured at the diagnosis time (light gray bars), after 5 years (dark gray bars) and after 10 years (black bars). The majority of patients had already portal vein enlargement at the diagnosis time. Spleen diameter increased in the observation period.

  1. Supplementary Table