Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2014, Article ID 672603, 9 pages
http://dx.doi.org/10.1155/2014/672603
Review Article

Clinical, Laboratory, and Therapeutic Analyses of 21 Patients with Neonatal Thrombosis and Antiphospholipid Antibodies: A Literature Review

1Universidade de Fortaleza (Unifor), 60811-905 Fortaleza, CE, Brazil
2Aliança Medical Center, 41920-000 Salvador, BA, Brazil
3Universidade Federal do Ceará (UFC), 60430-160 Fortaleza, CE, Brazil

Received 17 January 2014; Revised 1 July 2014; Accepted 7 July 2014; Published 17 July 2014

Academic Editor: Roger Levy

Copyright © 2014 Marcus Vinicius da Costa Peixoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. M. Soares Rolim, M. Castro, and M. B. Santiago, “Neonatal antiphospholipid syndrome,” Lupus, vol. 15, no. 5, pp. 301–303, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. J. H. Klippel, Primer on the Rheumatic Diseases, Springer, Atlanta, Ga, USA, 2007.
  3. A. Tincani, C. B. Rebaioli, L. Andreoli, A. Lojacono, and M. Motta, “Neonatal effects of maternal antiphospholipid syndrome,” Current Rheumatology Reports, vol. 11, no. 1, pp. 70–76, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Finazzi, S. Cortelazzo, P. Viero, M. Galli, and T. Barbui, “Maternal lupus anticoagulant and fatal neonatal thrombosis.,” Thrombosis and Haemostasis, vol. 57, article 238, 1987. View at Google Scholar · View at Scopus
  5. M. Sheridan-Pereira, R. P. Porreco, T. Hays, and M. S. Burke, “Neonatal aortic thrombosis associated with the lupus anticoagulant,” Obstetrics and Gynecology, vol. 71, no. 6, pp. 1016–1018, 1988. View at Google Scholar · View at Scopus
  6. R. K. Silver, S. N. MacGregor, J. F. Pasternak, and S. E. Neely, “Fetal stroke associated with elevated maternal anticardiolipin antibodies,” Obstetrics and Gynecology, vol. 80, no. 3, pp. 497–499, 1992. View at Google Scholar · View at Scopus
  7. S. Contractor, M. Hiatt, M. Kosmin, and H. C. Kim, “Neonatal thrombosis with anticardiolipin antibody in baby and mother,” American Journal of Perinatology, vol. 9, no. 5-6, pp. 409–410, 1992. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Tabbutt, W. R. Griswold, M. T. Ogino, A. E. Mendoza, J. B. Allen, and V. M. Reznik, “Multiple thromboses in a premature infant associated with maternal phospholipid antibody syndrome,” Journal of Perinatology, vol. 14, no. 1, pp. 66–70, 1994. View at Google Scholar · View at Scopus
  9. M. L. Hage, R. Liu, D. G. Marcherschi, J. D. Bowie, N. B. Allen, and B. G. Macik, “Fetal renal vein thrombosis, hydrops fetalis, and maternal lupus anticoagulant. A case report,” Prenatal Diagnosis, vol. 14, no. 9, pp. 873–877, 1994. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Teyssier, V. Gautheron, L. Absi, C. Galambrun, C. Ravni, and J. C. Lepetit, “Anticorps anticardiolipine, ischémie cérébrale et hémorragie surrénalienne chez un nouveau-né,” Archives de Pédiatrie, vol. 2, no. 11, pp. 1086–1088, 1995. View at Publisher · View at Google Scholar
  11. O. L. de Klerk, T. W. de Vries, and L. G. Sinnige, “An unusual cause of neonatal seizures in a newborn infant,” Pediatrics, vol. 100, no. 4, article E8, 1997. View at Google Scholar · View at Scopus
  12. F. Navarro, M. A. Doña-Naranjo, and I. Villanueva, “Neonatal antiphospholipid syndrome,” Journal of Rheumatology, vol. 24, no. 6, pp. 1240–1241, 1997. View at Google Scholar · View at Scopus
  13. L. F. Akanli, S. S. Trasi, K. Thuraisamy et al., “Neonatal middle cerebral artery infarction: association with elevated maternal anticardiolipin antibodies,” American Journal of Perinatology, vol. 15, no. 6, pp. 399–402, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Chow and D. Mellor, “Neonatal cerebral ischaemia with elevated maternal and infant anticardiolipin antibodies,” Developmental Medicine and Child Neurology, vol. 42, no. 6, pp. 412–413, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Tuohy and A. Harrison, “Prenatal transfer of anticardiolipin antibodies associated with fatal neonatal aortic thrombosis,” Australian and New Zealand Journal of Obstetrics and Gynaecology, vol. 45, no. 2, pp. 175–176, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Paro-Panjan, L. Kitanovski, and T. Avčin, “Neonatal antiphospholipid syndrome associated with heterozygous methylentetrahydrofolate reductase C677T and prothrombin G20210A gene mutations,” Rheumatology, vol. 46, no. 4, pp. 720–721, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Alshekaili, G. Reynolds, and M. C. Cook, “De novo infantile primary antiphospholipid antibody syndrome,” Lupus, vol. 19, no. 13, pp. 1565–1568, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Cabral, C. Abadesso, M. Conde, H. Almeida, and H. Carreiro, “Catastrophic antiphospholipid syndrome: first signs in the neonatal period,” European Journal of Pediatrics, vol. 170, no. 12, pp. 1577–1583, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. A. Bhat, M. S. Kawoosa, J. I. Bhat, and S. W. Ali, “Antiphospholipid syndrome in a neonate,” Pediatric Dermatology, vol. 28, no. 3, pp. 342–345, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. M. P. De Carolis, S. Salvi, I. Bersani, and S. De Carolis, “Isolated cerebral sinovenous thrombosis: a rare case of neonatal antiphospholipid syndrome,” Indian pediatrics, vol. 49, no. 5, pp. 411–412, 2012. View at Google Scholar · View at Scopus
  21. E. Merlin, E. Doré, S. Chabrier, M. Biard, A. Marques-Verdier, and J. Stéphan, “A case of infantile de novo primary antiphospholipid syndrome revealed by a neonatal arterial ischemic stroke,” Journal of Child Neurology, vol. 27, no. 10, pp. 1340–1342, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. P. R. Sousa, R. Figueira, and R. Vasconcellos, “Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation,” BMJ Case Reports, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Cervera, J. C. Piette, J. Font et al., “Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients,” Arthritis and Rheumatism, vol. 46, no. 4, pp. 1019–1027, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Wisloff, E. M. Jacobsen, and S. Liestol, “Laboratory diagnosis of the antiphospholipid syndrome,” Thrombosis Research, vol. 108, no. 5-6, pp. 263–271, 2002. View at Publisher · View at Google Scholar
  25. C. E. M. Rodrigues, J. F. Carvalho, and Y. Shoenfeld, “Neurological manifestations of antiphospholipid syndrome,” European Journal of Clinical Investigation, vol. 40, no. 4, pp. 350–359, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Motta, M. C. Boffa, A. Tincani, T. Avcin, S. de Carolis, and E. Lachassinne, “Follow-up of babies born to mothers with antiphospholipid syndrome: preliminary data from the European neonatal registry,” Lupus, vol. 21, no. 7, pp. 761–763, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Chang, “Neonatal autoimmune diseases: a critical review,” Journal of Autoimmunity, vol. 38, no. 2-3, pp. J223–J238, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Mekinian, E. Lachassinne, P. Nicaise-Roland et al., “European registry of babies born to mothers with antiphospholipid syndrome,” Annals of the Rheumatic Diseases, vol. 72, no. 2, pp. 217–222, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Boffa and E. Lachassinne, “Infant perinatal thrombosis and antiphospholipid antibodies: a review,” Lupus, vol. 16, no. 8, pp. 634–641, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Berkun, S. Padeh, J. Barash et al., “Antiphospholipid syndrome and recurrent thrombosis in children,” Arthritis Care & Research, vol. 55, no. 6, pp. 850–855, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. M. J. Simchen, G. Goldstein, A. Lubetsky, T. Strauss, E. Schiff, and G. Kenet, “Factor v leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic stroke,” Stroke, vol. 40, no. 1, pp. 65–70, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Cervera, M. C. Boffa, M. A. Khamashta, and G. R. V. Hughes, “The Euro-Phospholipid project: epidemiology of the antiphospholipid syndrome in Europe,” Lupus, vol. 18, no. 10, pp. 889–893, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Messinger, J. W. Sheaffer, J. Mrozek, C. M. Smith, and A. R. Sinaiko, “Renal outcome of neonatal renal venous thrombosis: review of 28 patients and effectiveness of fibrinolytics and heparin in 10 patients,” Pediatrics, vol. 118, no. 5, pp. e1478–e1484, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. K. B. Nelson, “Perinatal ischemic stroke,” Stroke, vol. 38, no. 2, pp. 742–745, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. W. Wu, W. M. March, L. A. Croen, J. K. Grether, G. J. Escobar, and T. B. Newman, “Perinatal stroke in children with motor impairment: a population-based study,” Pediatrics, vol. 114, no. 3, pp. 612–619, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. M. R. Golomb, B. P. Garg, C. Saha, F. Azzouz, and L. S. Williams, “Cerebral palsy after perinatal arteril ischemic stroke,” Journal of Child Neurology, vol. 23, no. 3, pp. 279–286, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. D. L. Longo, Harrinson's Principles of Internal Medicine, 18th edition, 2012.
  38. A. Hill and J. J. Volpe, “Neurologic disorders,” in Neonatology: Pathophysiology and Management of the Newborn, G. B. Avery, M. A. Fletcher, and M. G. MacDonald, Eds., pp. 1119–1120, JB Lippincott, Philadelphia, Pa, USA, 4th edition, 1994. View at Google Scholar
  39. F. Kotlarek, A. Thron, U. Weber et al., “Der Schlaganfall beim Kind: Ätiologie, Differentialdiagnose, sinnvolle Diagnostik und therapeutische Möglichkeiten,” Klinische Pädiatrie, vol. 205, pp. 332–339, 1993. View at Google Scholar
  40. H. Berman, I. Rodriguez-Pinto, R. Cervera et al., “Pediatric catastrophic antiphospholipid syndrome: descriptive analysis of 45 patients from the “CAPS Registry”,” Autoimmunity Reviews, vol. 13, no. 2, pp. 157–162, 2014. View at Publisher · View at Google Scholar
  41. M. E. Bauman, P. Cheung, and M. P. Massicotte, “Hemostasis and platelet dysfunction in asphyxiated neonates,” Journal of Pediatrics, vol. 158, no. 2, pp. e35–e39, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. M. P. Massicotte, M. G. Bousser, and M. E. Bauman, “Neonatal cerebral venous thrombosis: le debut,” Journal of Pediatrics, vol. 156, no. 5, pp. 695–696, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Chabrier, B. Husson, M. Dinomais, P. Landrieu, and S. N. T. Tich, “New insights (and new interrogations) in perinatal arterial ischemic stroke,” Thrombosis Research, vol. 127, no. 1, pp. 13–22, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Kurnik, A. Kosch, R. Sträter, R. Schobess, C. Heller, and U. Nowak-Göttl, “Recurrent thromboembolism in infants and children suffering from symptomatic neonatal arterial stroke: a prospective follow-up study,” Stroke, vol. 34, no. 12, pp. 2887–2892, 2003. View at Publisher · View at Google Scholar · View at Scopus