Research Article
Inhibition of Neutrophil Collagenase/MMP-8 and Gelatinase B/MMP-9 and Protection against Endotoxin Shock
Table 1
Peptide sequences and their IC50 values in μM against target enzymes.
| Peptide name | Peptide sequence | MMP-8 | MMP-9 | TACE | Reference |
| Regasepin 2 | Pro-Pyr-Cys-Bip-Arg-Gly-Glu | 10 | 0.8 | 1.5 | [9] |
| Regasepin 1 | Pro-Arg-Cys-Bip-Cys-Gly-Glu | 3 | 1.5 | 5 | [8] |
| Inhibitor 2 | Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu | 0.8 | 2.75 | 5.5 | [11] |
| ES-2 | Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro | >500 | >500 | >500 | [10] |
| P2 | Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu-Gly-Gly-Gly-Gly-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro | 0.35 | 1.36 | 1.95 | [10] |
| HM-3 | Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp | ND | ND | ND | [12] |
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