Warifteine, an Alkaloid Purified from Cissampelos sympodialis, Inhibits Neutrophil Migration In Vitro and In Vivo
Figure 5
Number of polymorphonuclear leukocytes in the bone marrow and peripheral blood of mice treated with casein and warifteine. Mice were treated with warifteine, casein, or both substances. After a three-hour period past casein treatment, bone marrow (a) and blood samples (b) were obtained. Blood smears and bone marrow cytospins were analyzed by optical microscopy after staining. The graph shown in (a) indicates the mean value from data obtained in two experiments ( animals per group). when comparing the group of animals treated with casein with untreated animals (controls). There was no statistical difference between the group treated with casein and the one treated with warifteine plus casein. Data shown in (b) indicate the percentage of blood neutrophils in different groups and are the mean value from three independent experiments ( animals per group/experiment). when comparing animals treated with casein with the untreated ones and in the comparison of the groups of animals treated with warifteine and casein with the group treated with casein only.
