Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia following Japanese Encephalitis Virus Infection

Figure 8

Proinflammatory cytokines and chemokines induced by JEV in TLR3 and RIG-I knockdown BV-2 cells. BV-2 cells were transfected with RIG-I shRNA (RIG-I KD), TLR3 shRNA (TLR3 KD), or negative control shRNA (CTR) and then infected with JEV at an MOI of 1. The production of TNF-α (a, d), IL-6 (b, e), and CCL-2 (c, f) was measured with ELISA. Error bars represent the standard deviation of results from three independent assays (^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001).

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