The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment
Figure 3
Induction of local and widespread antitumor reactivity with continuous cytokine infusion into tumors. Recombinant human GM-CSF was administered continuously into the tumor of a patient with pleural mesothelioma using a pump attached to an intratumoral cathers via a subcutaneous port (a) Tumor biopsies (H&E) taken before (b) and after (c) 8 weeks of continuous intratumoral infusion of GM-CSF. Shown is a marked influx of immune cells into uninfused tumor following the therapy. This patient exhibited a generalized partial response (>50% diffuse tumor reduction).
