Journal of Immunology Research / 2014 / Article / Tab 4 / Research Article
Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus Table 4 Associations between specific autoantibodies and clinical manifestations of SLE
patient number (%)
.
Anti-dsDNA Anti-Sm Anti-RNP Anti-SSA Anti-SSB Anti-rRNP APL Positive
Positive
Positive
Positive
Positive
Positive
Positive
Patients number 699 (100) 350 (100) 189 (100) 497 (100) 224 (100) 255 (100) 414 (100) Malar rash 315 (45.06) 0.061 201 (57.43) <0.001* 91 (48.15) 0.956 241 (48.49) 0.785 105 (46.88) 0.732 151 (59.22) 0.004* 187 (45.17) 0.275 Discoid lesions 31 (4.43) 0.099 22 (6.29) 0.546 13 (6.88) 0.426 25 (5.03) 0.522 11 (4.91) 0.631 13 (5.10) 0.855 20 (4.83) 0.540 Photosensitivity 150 (21.46) 0.008* 95 (27.14) 0.311 47 (24.87) 0.965 132 (26.56) 0.358 67 (29.91) 0.073 69 (27.06) 0.752 96 (23.19) 0.509 Oral ulcerations 151 (21.6) 0.671 87 (24.86) 0.181 42 (22.22) 0.980 108 (21.73) 0.797 48 (21.43) 0.784 48 (18.82) 0.395 74 (17.87) 0.035* Arthritis 399 (57.08) 0.095 193 (55.14) 0.796 106 (56.08) 0.650 268 (53.92) 0.762 119 (53.13) 0.658 146 (57.25) 0.765 236 (57.00) 0.289 Serositis 119 (17.02) 0.584 55 (15.71) 0.705 31 (16.40) 0.999 89 (17.91) 0.298 46 (20.54) 0.077 35 (13.73) 0.428 61 (14.73) 0.996 Nephropathy 355 (50.79) 0.030* 155 (44.29) 0.196 91 (48.15) 0.837 216 (43.46) 0.042* 102 (45.54) 0.547 120 (47.06) 0.817 191 (46.14) 0.848 Hematological involvement 403 (57.65) 0.321 196 (56.00) 0.957 108 (57.14) 0.769 278 (55.94) 0.920 141 (62.95) 0.030* 137 (53.73) 0.542 273 (65.94) <0.001* Neurological involvement 26 (3.72) 0.102 18 (5.14) 0.743 12 (6.35) 0.296 21 (4.23) 0.493 13 (5.80) 0.457 16 (6.27) 0.335 32 (7.73) 0.061 ILD
(4.30)0.941
(5.52)0.214
(6.08)0.201
(4.37)0.884
(5.74)0.259
(4.80)0.940
(7.29)<0.001* PAH
(3.63)0.747
(4.97)0.242
(6.67)0.037*
(5.97)0.005*
(5.37)0.224
(2.11)0.151
(3.88)0.714
:
value; Anti-dsDNA: Anti-double stranded DNA antibody; Anti-Sm: Anti-Sm antibody; Anti-SSA: Anti-SSA antibody; Anti-SSB: Anti-SSB antibody; Anti-RNP: Anti-u1 small-nuclear RNA-protein antibody; Anti-rRNP: Anti-ribosomal RNA-protein antibody; APL: Anti-phospholipid antibody; PAH: pulmonary arterial hypertension; ILD: interstitial lung disease.
Actually detected number of patients.
.