Targeted Inhibition of mTOR Signaling Improves Sensitivity of Esophageal Squamous Cell Carcinoma Cells to Cisplatin
Figure 4
Protein expression of effectors in mTOR pathway of EC9706 xenografts treated with different ways. (a) Antibodies to mTOR, p70S6K, p-p70S6K, 4EBP1, and p-4EBP1, respectively. (b) Semiquantitative values of bands from three independently repeated experiments, which were statistically analyzed by densitometry using TotalLab 2.0 software, are expressed as means ± SD. Reduced expressions of mTOR, p-p70S6K, and p-4EBP1 and elevated expressions of p70S6K and 4EBP1 were observed in groups treated with mTOR siRNA and mTOR siRNA combined with cisplatin. -Actin was used as loading control. , compared to control group.
