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Journal of Immunology Research
Volume 2014 (2014), Article ID 857143, 17 pages
http://dx.doi.org/10.1155/2014/857143
Review Article

The Role of Dendritic Cells in Tissue-Specific Autoimmunity

1Center for Health Disparities and Molecular Medicine, 11085 Campus Street, Mortensen Hall, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
2Endocrinology Section, JL Pettis Memorial VA Medical Center, Loma Linda, CA 92354, USA

Received 27 December 2013; Revised 20 March 2014; Accepted 8 April 2014; Published 30 April 2014

Academic Editor: Loredana Frasca

Copyright © 2014 Jacques Mbongue et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is becoming clear that we are only at the beginning of understanding the role of these antigen presenting cells in mediating autoimmunity. Emerging research areas for the study of dendritic cell involvement in the onset and inhibition of tissue-specific autoimmunity are presented. Further, we compare tissue specific to systemic autoimmunity to demonstrate how development of dendritic cell-based therapies may be broadly applicable to both classes of autoimmunity. Continued development of these research areas will lead us closer to clinical assessment of novel immunosuppressive therapy for the reversal and prevention of tissue-specific autoimmunity. Through description of dendritic cell functions in the modulation of tissue-specific autoimmunity, we hope to stimulate a greater appreciation and understanding of the role dendritic cells play in the development and treatment of autoimmunity.