Increased Levels of Granulocytic Myeloid-Derived Suppressor Cells in Peripheral Blood and Tumour Tissue of Pancreatic Cancer Patients

Table 2

Frequency of MDSC subsets in the peripheral blood of healthy donors, chronic pancreatitis, and pancreatic cancer patients.

	PC	CP	HDs	𝑃 value
Lin-HLA-DR-	2.7 (0.7–17.5)*	1.9 (1–90.7)*	4.3 (1.0–14.6)*	A = 0.14, B = 0.59, C = 0.79
Lin-HLA-DR-CD33+11b+	8.1 (1.4–27.6)*	11.8 (0.5–34.2)*	8.7 (0–19.2)*	A = 0.6, B = 0.85, C = 0.89
Lin-HLA-DR-CD33+11b+CD15+	8.8 (0–91.3)*	8.9 (0–33.7)*	1.4 (0–14.5)*	A  =  0.0003, B = 0.65, C = 0.13
Lin-HLA-DR-CD14+	0.8 (0.2–6.6)*	1.6 (0.4–6.3)*	1.3 (0.16–3.5)*	A = 0.47, B = 0.43, C = 0.63
HLA-DR-/^lowCD14+	0.9 (0.2–7.5)*	2.2 (0.2–37.1)*	1.8 (0.6–6.7)*	A = 0.41, B = 0.83, C = 0.79
HLA-DR-/^LowCD33+	10.5 (1.9–31.2)*	14.8 (0.4–93.1)*	14.2 (1.4–23.9)*	A = 0.69, B = 0.818, C = 0.89

PC: pancreatic cancer; CP: chronic pancreatitis; HDs: healthy donors. P value: A = (PC versus HDs); B = (PC versus CP); C = (CP versus HDs).∗Data shown represent median (range). The bold values refer to statistically significant 𝑃 values.