CD8+ TIL Recruitment May Revert the Association of MAGE A3 with Aggressive Features in Thyroid Tumors

Table 1

MAGE A3 expression levels according to visual (semiquantitative) IHC in benign and malignant thyroid nodules and in different follicular patterned lesions including classic (CPTC), follicular variant papillary thyroid carcinomas (FVPT), follicular carcinoma (FTC), and follicular adenoma (FA).

Analyzed groups	value (semiquantitative IHC)	Semiquantitative IHC		Predictive value
		Sensitivity (%)	Specificity (%)	Positive (%)	Negative (%)
Malignant versus benign	<0.0001	94.87	32.35	72.83	76.74
CPTC versus goiter	<0.0001	96.04	49.06	78.86	86.21
CPTC versus FA	0.0215	96.04	15.96	69.29	66.67
CPTC versus variants	N.S.	96.04	0.94	66.90	55.56
FVPTC versus goiter	<0.0001	89.80	49.02	62.86	83.33
FVPTC versus FA	N.S.	89.80	15.69	50.57	61.54
FVPTC versus FTC	N.S.	97.56	10.20	47.62	83.33
FTC versus FA	0.0396	97.56	15.69	48.19	88.89
FTC versus goiter	<0.0001	97.56	49.02	60.61	96.15
FA versus goiter	0.0006	84.31	49.02	62.32	75.76