Review Article
Cytokine Network Involvement in Subjects Exposed to Benzene
Table 2
Summary of considered studies on atopy induced by benzene and/or its metabolites.
| Population | Exposure substance(s) | Effect(s) | Reference |
| Nonatopic and atopic women | Vehicular traffic and low air pollution | No difference in urinary trans,trans-muconic acid | Boscolo et al., 2000 [39] | Nonatopic and atopic women | Vehicular traffic and low air pollution | Stimulation of NK activity | Boscolo et al., 2000 [39] | 3-year-old children | Chlorobenzene | Contribution to the risk of allergic sensitization to the food allergens milk and egg white | Lehmann et al., 2001 [40] | 3-year-old children | Benzene, ethylbenzene, and chlorobenzene | Increased IL-4 producing CD3+ T cells | Lehmann et al., 2001 [40] | Healthy subjects | HQ, benzenetriol, BQ, and catechol | Increased secretion of IL-4 | Gillis et al., 2007 [21] | Healthy subjects | HQ, catechol | Increased secretion of IL-5 | Gillis et al., 2007 [21] |
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HQ: hydroquinone; BQ: benzoquinone.
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