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Journal of Immunology Research
Volume 2014, Article ID 963484, 8 pages
Review Article

The Role of the γδ T Cell in Allergic Diseases

Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China

Received 30 March 2014; Accepted 11 May 2014; Published 3 June 2014

Academic Editor: Qifa Liu

Copyright © 2014 Rui Zheng and Qintai Yang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The predominant distribution of γδ T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the “guards” to contact external environment (like allergens) and to contribute to immune surveillance, as well as “vanguards” to participate in initiating mucosal inflammation. Therefore, γδ T cells have been considered to bridge the innate and adaptive immunity. The role these cells play in allergy seems to be complicated and meaningful, so it makes sense to review the characteristics and role of γδ T cells in allergic diseases.