IL-6 as a Druggable Target in Psoriasis: Focus on Pustular Variants

Figure 1

IL-6 signalling pathways. In classical signalling (red star), cells expressing membranous IL-6R are responsive to IL-6; in transsignalling (yellow star), cells lacking IL-6R are activated by IL-6/sIL-6R complexes (sIL-6R is generated by proteolytic shedding from IL-6R via ADAM10 and ADAM17 or by mRNA alternative splicing). Cellular events initiated by IL-6/IL-6R activity include activation of JAK, MEKs-ERKs, and PI3K/Akt kinases, resulting in changes in nuclear gene expression. IL-6: interleukin 6; sIL-6R: soluble interleukin 6 receptor.