The Relevance of HLA Sequencing in Population Genetics Studies

Table 1

Number (#) and proportion (%) of HLA alleles defined at the second, third, and fourth fields of the current HLA nomenclature (IMGT/HLA database release 3.15.0, 2014-01-17). The third field (highlighted in bold) is defined by synonymous nucleotide substitutions in coding regions.

Locus	Total	Second field		Third field		Fourth field
	#	#	%	#	%	#	%
A	2579	1862	72.2%	691	26.8%	26	1.0%
B	3285	2404	73.2%	858	26.1%	23	0.7%
C	2133	1486	69.7%	616	28.9%	31	1.5%
DRA	7	0	0.0%	4	57.1%	3	42.9%
DRB1	1411	972	68.9%	429	30.4%	10	0.7%
DQA1	51	23	45.1%	13	25.5%	15	29.4%
DQB1	509	318	62.5%	181	35.6%	10	2.0%
DPA1	37	15	40.5%	17	45.9%	5	13.5%
DPB1	248	198	79.8%	46	18.5%	4	1.6%