SNP Gene Function† Association with References Ps type I Ps type II Ps type I versus type II — X X [6 –10 ] — X [8 ] rs1265181 HLA-C Encodes a class I molecule which plays a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen X X [11 ] rs12191877 [7 , 11 ] rs4406273 X X [11 ] rs2395029 X [11 ] rs10484554 X X X [7 , 10 , 12 ] rs13191099 X [4 ] rs10876882 HLA-A X [4 ] rs33980500 TRAF3IP2 Encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappa-B transcription factor family X [11 ] rs71562288 X [4 ] rs2233278 TNIP1 Encodes A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation X [11 ] rs17728338 TNIP1 X [11 ] rs1295685 IL13 Encodes a cytokine involved in several stages of B cell maturation and differentiation X [11 ] rs17716942 IFIH1 Encodes an Asp-Glu-Ala-Asp box protein (putative RNA helicases) X [7 ] rs1990760 X [4 ] rs27524 ERAP1 Encodes an aminopeptidase involved in trimming HLA class I-binding precursors X [6 ]# rs11209026 IL23R Encodes a subunit of the receptor for IL23A/IL23 X [6 ]# rs72676067 X [4 ] rs10876882 IL23A Encodes a subunit of IL23 involved in immune responses X [4 ] — LCE3B/LCE3C-del Encodes precursors of the cornified envelope of the stratum corneum X [6 , 13 ]# rs2546890 IL12B Encodes a subunit of IL12 that acts on T and natural killer cells X X [4 , 14 ] rs60813083 RNF114 Encodes a protein that may play a role in spermatogenesis X [4 ] rs887998 IL1R1 Encodes a receptor for IL1 involved in inflammatory responses X [4 ] rs16944 IL1B Encodes a cytokine produced by activated macrophages and is involved in immune responses, cell proliferation, differentiation, and apoptosis X [4 , 15 ] rs2853550 X [4 ] rs26653 ERAP1 Encodes an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on the MHC class I molecule X [10 ] rs30187 X [10 ] rs2227473 IL22 Encodes an interleukin 22 that contributes to the inflammatory response X [16 ] rs2227483 X [16 ] INDEL rs35774195/rs10784699 X [16 ] rs6822844 IL2/IL21 Encode cytokines that are important in the innate and adaptive immune responses by inducing differentiation, proliferation, and activity of multiple target cells including macrophages, natural killer cells, B cells, and cytotoxic T cells X [17 ]
rs2069778 X [17 ] rs6311 HTR2A Encodes a receptor for neurotransmitter serotonin X [18 ] rs12459358 PSORS6 Encodes genetic locus associated with susceptibility to psoriasis X [19 ] rs1800629 TNF-α Encodes a cytokine secreted by macrophages and involved in the regulation of cell proliferation, differentiation, and apoptosis, as well as in lipid metabolism and coagulation X [20 , 21 ] rs361525 X [15 , 20 –24 ] rs3733197 BANK1 Encodes a protein involved in B cell receptor-induced calcium mobilization from intracellular stores X [25 ] rs755622 MIF Encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation X X [26 ] rs6693899 IL10 Encodes a cytokine produced by monocytes and lymphocytes and involved in immunoregulation and inflammation X X [27 ] rs1800896 X [28 ] rs4341 ACE Encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II X [29 ] SNPs at positions -1540, -1512, -1451, -460, and -152 VEGFA Encodes a protein involved in angiogenesis, vasculogenesis, endothelial cell growth, promotion of cell migration, and inhibition of apoptosis X [30 ] SNPs at positions -386 and -404 CCHCR1 Encodes a protein that may be a regulator of keratinocyte proliferation or differentiation X [31 ] — X [9 ]
