Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis

Table 2

Results of univariate linear regression analysis (unadjusted and adjusted for rs12191877 in HLA-C) and multivariate linear regression analysis (155 patients with type I psoriasis versus 197 controls). In the multivariate analysis, we included the SNPs with in the univariate analysis adjusted for HLA-C. Only polymorphisms that were significant in the multivariate analysis are shown.

SNP	Gene	Model	Risk genotype	Univariate unadjusted. Type I; patients versus controls		Univariate adjusted for; HLA-C		Multivariate
				OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value
rs2282276	CLMN	A	CC/CT	1.74 (0.96–3.15)	0.066	1.95 (1.04–3.65)	0.037	3.90 (1.13–13.38)	0.031
rs10782001	FBXL19	A	GG/AG	1.58 (1.13–2.21)	0.007	1.59 (1.09–2.32)	0.016	2.10 (1.05–4.17)	0.035
rs1634517	CCL4L	D	AA/AC	0.89 (0.58–1.36)	0.590	0.64 (0.39–1.05)	0.073	0.34 (0.14–0.84)	0.019
rs1975974	C17orf51	A	GG/AG	0.80 (0.57–1.14)	0.220	0.66 (0.44–0.99)	0.040	0.48 (0.23–0.99)	0.048
rs12720356	TYK2	A	GG/GT	0.42 (0.21–0.81)	0.019	0.27 (0.13–0.58)	0.0003	0.10 (0.03–0.39)	0.001
rs1800925	IL13	R	TT	0.18 (0.02–1.45)	0.051	0.17 (0.02–1.49)	0.061	0.01 (0.00–0.73)	0.034
rs3792876	SLC22A4	A	TT/CT	1.57 (0.89–2.76)	0.110	1.87 (0.98–3.55)	0.057	3.75 (1.19–11.83)	0.024
rs6908425	CDKAL1	A	TT/CT	0.67 (0.47–0.97)	0.029	0.58 (0.39–0.89)	0.01	0.41 (0.20–0.85)	0.017
rs12191877	HLA-C	A	TT/CT	5.92 (3.83–9.15)		—	—	30.54 (10.62–87.85)	0.000
rs13437088	HLA-B/MICA	D	TT/CT	2.17 (1.42–3.34)		1.93 (1.19–3.13)	0.007	2.52 (1.01–6.31)	0.048

CLMN: calponin-like transmembrane gene; FBXL19: F-box and leucine-rich repeat protein 19; CCL4L: chemokine (C-C motif) ligand 4-like; C17orf51: chromosome 17 open reading frame 51; TYK2: nonreceptor tyrosine-protein kinase; IL13: interleukin 13; SLC22A4: solute carrier family 22 member 4; CDKAL1: cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1; HLA: major histocompatibility complex; MICA: major histocompatibility complex class I polypeptide-related sequence A; SNPs: single-nucleotide polymorphisms; OR: odds ratio of presenting type 1 psoriasis; CI: confidence interval; A: additive; R: recessive; D: dominant; —: no data.