fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils

Figure 2

NADPH oxidase inhibition reduces ROS production. Neutrophils incubated with 50 or 500 μM HMAP (a), 1 or 10 μM DPI (b), or vehicle for 10 min were stimulated with 100 nM fMLP, and ROS production was detected by luminescence assay. In (c), the effect of NADPH oxidase inhibitors on AUC for 700 seconds (AUC₇₀₀) of ROS production is shown. Mean ± SE; compared to fMLP; .

(a)

(b)

(c)