Modulation of Th1/Th2 Immune Responses by Killed Propionibacterium acnes and Its Soluble Polysaccharide Fraction in a Type I Hypersensitivity Murine Model: Induction of Different Activation Status of Antigen-Presenting Cells

Table 1

Schematic representation of P. acnes and PS effects on co-stimulatory molecules and TLRs expression in Protocols 1 and 2. P. acnes and PS effects on co-stimulatory molecules (a) and TLRs (b) expression in Protocols 1 and 2 are summarized and represented as different symbols. (●) indicates up-regulation, while (○) indicates down-regulation of each molecule compared to the control group. (—) indicates that there was no difference in the expression of the molecule in relation to the control group.

(a)

	Protocol 1			Protocol 2
	B	M	DC	B	M	DC
CD40	—	●	●	—	○	—
CD80	—	●	●	○	—	●
CD86	—	●	●	○	—	—
PS	Protocol 1			Protocol 2
	B	M	DC	B	M	DC
CD40	—	●	●	—	○	○
CD80	●	●	●	—	○	—
CD86	●	●	●	○	○	○

(b)

	Protocol 1			Protocol 2
	B	M	DC	B	M	DC
TLR2	○	—	—	●	—	●
TLR4	—	○	—	●	—	●
exTLR9	—	—	○	●	●	—
inTLR9	●	●	○	●	○	●
PS	Protocol 1			Protocol 2
	B	M	DC	B	M	DC
TLR2	—	●	—	—	●	—
TLR4	—	—	—	—	●	—
exTLR9	●	●	—	●	●	—
inTLR9	—	●	○	—	—	●