Herpes Murine Model as a Biological Assay to Test Dialyzable Leukocyte Extracts Activity

Figure 2

Validation of the murine herpes model for the evaluation of Transferon activity. (a) Survival curves for HSV-1 infected mice. Treatments with 1 μg (open triangles) or 0.125 μg (open squares) of Transferon improved survival over placebo (open circles; Log-rank Mantel-Cox test; ). In contrast, 12.5 ng of Transferon (open diamonds) had no significant effect. A group of mice was left uninfected (closed circles) as control. (b) Weight changes in HSV-1 infected mice. Transferon partially protects mice from the weight loss induced by HSV-1 (symbols are as in (a)). (c) Survival induced by five different Transferon batches was evaluated during a validation protocol. All batches improved survival versus placebo (Bonferroni t test; , ; ).

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