Endothelin Receptors Expressed by Immune Cells Are Involved in Modulation of Inflammation and in Fibrosis: Relevance to the Pathogenesis of Systemic Sclerosis

Table 3

Detection of cytokines in the supernatants of CD4+ T lymphocytes after 24 hours of incubation with ET-1 alone or with selective or dual receptors blockade. One million cells were incubated in each cell culture condition.

	Control cells	Cells with ET-1	Cells with ET-1 and ETA antagonist	Cells with ET-1 and ETB antagonist	Cells with ET-1 and dual receptor blockade
INF- (pg/mL)	0.8 ± 0.2	7.6 ± 0.2	1.2 ± 0.45	1.6 ± 0.6	0 ± 0.1
IL-4 (pg/mL)	78.1 ± 74.3	60.8 ± 80.2	711.42 ± 102.2	694.47 ± 99.8	682 ± 100.6
IL-17 (pg/mL)	28.7 ± 10.2	36.1 ± 11.1	37.2 ± 9.8	35.6 ± 12.3	36.6 ± 10.8