Endothelin Receptors Expressed by Immune Cells Are Involved in Modulation of Inflammation and in Fibrosis: Relevance to the Pathogenesis of Systemic Sclerosis

Table 4

Molecules detected in neutrophils supernatants after 1, 3, or 10 hours of incubation with either no stimulus or ET-1, LPS, and ET-1 plus LPS, respectively.

	No stimulus			ET-1			LPS			ET-1 + LPS
Time of incubation	1	3	10	1	3	10	1	3	10	1	3	10
IL8 (pg/mL)	5.38	6.92	16.92	7.69	7.69	16.92	31.54	59.23	93.85	18.46	67.69	134.6
TNFα (pg/mL)	0	0	0	0	0	23.4	0	0	0	0.7	0	2.1
MMP9 (ng/mL)	46.4	67.8	58.8	165.1	64.7	63.3	131.3	203.8	205.3	102.9	205.6	220.7
VEGF (pg/mL)	18.58	20.42	28.75	16.25	22.1	28.7	33.75	52.92	57.92	32.08	54.58	56.25
INFγ (pg/mL)	0.28	0	0	1.94	0	0.28	14.17	0	0	0	0	0
IL17 (pg/mL)	0	0	0	0	0	3.5	0	0	0	0	0	0