Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL

Figure 1

The workflow of genetic association study of ATG5 by trans-eQTL. (a) eQTL: expression quantitative trait loci, eSNP: expression single nucleotide polymorphism, HWE: Hardy-Weinberg equilibrium, LN: lupus nephritis, MAF: minor allele frequency, PCA: principle component analysis, and SLE: systemic lupus erythematosus. (b) The online eQTL database: mRNA by SNP Browser v 1.0.1, http://www.sph.umich.edu/csg/liang/imputation/byGene.html. (c) HaploReg v3 database: http://www.broadinstitute.org/mammals/haploreg/haploreg_v3.php. RegulomeDB database: http://regulome.stanford.edu/. (d) GENEVAR project: the Gene Expression Variation project, http://www.sanger.ac.uk/humgen/genevar/. (e) The ArrayExpress Archive database: http://www.ebi.ac.uk/arrayexpress/.