Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL
Table 1
Allelic association analyses of the positive trans-eSNPs of ATG5 in LN.
Chr
Position
Locus
SNP (minor allele)
MAF Case/ control (%)
Allele OR by minor allele (95% CI)
Allele values
Current population
Combined with HapMap CHB population
4
124718662
5′ of ANKRD50
rs17008504(A)
19.2/26.9
0.645 (0.476, 0.875)
0.005
—
4
177438525
AGA
rs2271100(G)
16.1/10.6
1.630 (1.105, 2.405)
0.014
0.012
20
9840271
5′ of PAK7
rs6056923(G)
4.9/8.5
0.546 (0.326, 0.916)
0.022
—
4
105207603
TET2
rs1391441(G)
49.8/42.3
1.345 (1.039, 1.743)
0.025
0.002
14
36867767
SLC25A21
rs712377(C)
42.3/36.4
1.283 (0.984, 1.671)
0.065
0.146
4
105230686
TET2
rs1391438(G)
51.6/45.7
1.266 (0.978, 1.638)
0.073
0.009
8
69280407
3′ of CPSF6
rs10878953(G)
45.0/39.2
1.268 (0.977, 1.647)
0.075
—
1
108823932
AKNAD1
rs7529592(G)
9.0/12.3
0.701 (0.463, 1.062)
0.094
0.080
2
181482227
ITGA4
rs155098(G)
35.3/30.2
1.264 (0.960, 1.665)
0.095
—
6
21127081
CDKAL1
rs7751485(G)
34.8/29.3
1.286 (0.975, 1.698)
0.096
—
10
88787819
3′ of LIPN
rs7081173(A)
50.2/44.7
1.245 (0.962, 1.611)
0.096
0.116
(a) CHB: Han Chinese in Beijing, 95% CI: 95% confidence interval, chr: chromosome, LN: lupus nephritis, OR: odds ratio, SNP: single nucleotide polymorphism. (b) values were calculated by chi-square test using 2 × 2 contingency tables based on allele frequencies.
(c) None of the genotypes in the controls or patients showed significant deviation from Hardy-Weinberg equilibrium. (d) Chromosome positions were referred to GRCh38.
