Journal of Immunology Research / 2015 / Article / Tab 1

Research Article

Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL

Table 1

Allelic association analyses of the positive trans-eSNPs of ATG5 in LN.

Chr Position Locus SNP
(minor allele)
MAF Case/
control (%)
Allele OR by minor
allele (95% CI)
Allele values
Current populationCombined with HapMap CHB population

41247186625′ of ANKRD50rs17008504(A)19.2/26.90.645
(0.476, 0.875)
0.005
4177438525AGArs2271100(G)16.1/10.61.630
(1.105, 2.405)
0.0140.012
2098402715′ of PAK7rs6056923(G)4.9/8.50.546
(0.326, 0.916)
0.022
4105207603TET2rs1391441(G)49.8/42.31.345
(1.039, 1.743)
0.0250.002
1436867767SLC25A21rs712377(C)42.3/36.41.283
(0.984, 1.671)
0.0650.146
4105230686TET2rs1391438(G)51.6/45.71.266
(0.978, 1.638)
0.0730.009
8692804073′ of CPSF6rs10878953(G)45.0/39.21.268
(0.977, 1.647)
0.075
1108823932AKNAD1rs7529592(G)9.0/12.30.701
(0.463, 1.062)
0.0940.080
2181482227ITGA4rs155098(G)35.3/30.21.264
(0.960, 1.665)
0.095
621127081CDKAL1rs7751485(G)34.8/29.31.286
(0.975, 1.698)
0.096
10887878193′ of LIPNrs7081173(A)50.2/44.71.245
(0.962, 1.611)
0.0960.116

(a) CHB: Han Chinese in Beijing, 95% CI: 95% confidence interval, chr: chromosome, LN: lupus nephritis, OR: odds ratio, SNP: single nucleotide polymorphism.
(b) values were calculated by chi-square test using 2 × 2 contingency tables based on allele frequencies.
(c) None of the genotypes in the controls or patients showed significant deviation from Hardy-Weinberg equilibrium.
(d) Chromosome positions were referred to GRCh38.