Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL

Table 2

Correlation between genotypes of the positive trans-eSNP with ATG5 expression in public databases.

Gene	Children LCL ()		HapMap LCL ()
	Positive trans-eSNPs		SNP^d
ANKRD50	rs17008504	9.10 × 10^−5	rs1027497	0.92	0.001
AGA	rs2271100	1.20 × 10^−4	rs2271100	1	0.002
PAK7	rs6056923	1.10 × 10^−4	rs6056922	1	0.001
TET2	rs1391441	5.90 × 10^−6	rs1391441	1	0.005
TET2	rs1391438	7.10 × 10^−6	rs7655890	0.99	0.003
SLC25A21	rs712377	6.70 × 10^−5	rs712377	1	0.037
CPSF6	rs10878953	6.40 × 10^−5	rs7308481	0.99	0.030
AKNAD1	rs7529592	6.00 × 10^−5	rs7529592	1	0.001
ITGA4	rs155098	1.20 × 10^−4	rs155099	1	0.136
CDKAL1	rs7751485	1.00 × 10^−6	rs10946430	0.97	0.215
LIPN	rs7081173	1.50 × 10^−4	rs7081173	1	0.054

(a) LCL: lymphoblastoid cell lines, trans-eSNP: trans-expression single nucleotide polymorphism.
(b) Children LCL refers to lymphoblastoid cell lines from 400 children from families recruited through a proband with asthma.
(c) HapMap LCL refers to Epstein-Barr virus-transformed lymphoblastoid cell lines from 270 HapMap CEU, CHB, JPT, and YRI individuals (http://www.sanger.ac.uk/humgen/genevar/).
(d) Only the SNP on each locus with strongest associated significance with ATG5 expression level was shown.