Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus

Table 1

Advantages and disadvantages of different immunoassays currently utilized in GAS research.

Immunoassay	Advantages	Disadvantages
ELISA	High-throughput	May measure non-functional antibodies
	Easily standardized
	Reproducible
Bactericidal assays	Measures functional antibodies	Labour-intensive
		Inter-assay variability
		Use of whole human blood imposes two hour time restriction
		No controls for DBT